Untitled

Abstract

The in vitro drug release profile of hydrocortisone (HC) from creams, ointments, and lotions has been determined using an automated procedure. A diffusion cell system and commercially available synthetic membranes were utilized for the studies. The use of a synthetic membrane obviates the problems associated with using skin membranes. Uniform creams and ointment samples for determining release rate profile were prepared by using the teflon mask. Automated sampling avoids operator artifacts. The automated technique developed for determining the in vitro release rate profile of the drug from creams, ointments, and lotions using a diffusion-cell system appears to be a reasonable and practical procedure for assuring batch-to-batch uniformity of topical drug products.

Relationship between In Vivo Skin Blanching and In Vitro Release Rate for Betamethasone Valerate Creams

“…Shah et al have developed a simple, reliable, and reproducible test procedure to study the release rate of hydrocortisone, a water-soluble drug, from the cream preparation.3. 4 The method employs a diffusion cell system with commercially available synthetic membranes.…”

Investigation of the Release Test Method for the Topical Application of Pharmaceutical Preparations: Release Test of Cataplasm Including Nonsteroidal Anti-inflammatory Drugs Using Artificial Sweat

“…It is clear from Table 4 that the swelling of 9 kinds of cataplasm can be suppressed by changing the ion concentration in the dissolution medium. As the formulation of cataplasm varies from manufacturer to manufacturer, 6) AS of different ionic concentration is necessary for each cataplasm. Although it is specified in the USP that the sink condition was maintained throughout the experiment, when using the large holder IMcontaining products did not satisfy this condition.…”

“…[3][4][5][6] In addition, an aqueous solution should be used as the dissolution medium to minimize any environmental pollution, although release test results using organic solvents have been reported. 6,7) One of the major problems encountered during the development of the release method using aqueous solution is the cataplasm swelling due to the penetration of water, because the cataplasm consists of water-soluble polymers. Since it has been reported that this swelling of water-soluble polymer is suppressed by some metal ions, 8,9) the use of artificial sweat (AS) was investigated as a dissolution medium in this paper.…”

In Vitro Release Testing of Semi-Solid Dosage Forms

“…Upon leaving the cell, the eluate is filtered and can then be analyzed directly or collected in fractions to calculate the percent drug release (52). Several other automated and flow-through methods have also been used (30,31,(53)(54)(55)(56). An "insertion cell" used in conjunction with a compendial flow-through cell (USP) has been described by Chatteraj and Kanfer (31) where the release of acyclovir from semisolid dosage forms was monitored.…”