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Allen, J. T.; Horwell, David C.; Lainton, Julia A.H.; O'Neill, Jacqueline A.; Ratcliffe, Giles S.

doi:10.1023/a:1008845610432

Cited by 4 publications

(5 citation statements)

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“…Also, protein chaperones could be added for some challenging crystallizations (Ostermeier et al, 1995;Tereshko et al, 2008). In the same spirit, it would be interesting to investigate what could be done with molecules designed to mimic protein-protein interactions (Allen et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

The MORPHEUS protein crystallization screen

2009

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A 96-condition initial screen for protein crystallization, called MORPHEUS, has been developed at the MRC Laboratory of Molecular Biology, Cambridge, England (MRC-LMB). The concept integrates several innovative approaches, such as chemically compatible mixes of potential ligands, new buffer systems and precipitant mixes that also act as cryoprotectants. Instead of gathering a set of crystallization conditions that have already been successful, a selection of molecules frequently observed in the Protein Data Bank (PDB) to co-crystallize with proteins has been made. These have been put together in mixes of similar chemical behaviour and structure, and combined with buffers and precipitant mixes that were also derived from PDB searches, to build the screen de novo. Observations made at the MRC-LMB and many practical aspects were also taken into account when formulating the screen. The resulting screen is easy to use, comprehensive yet small, and has already yielded a list of crystallization hits using both known and novel samples. As an indicator of success, the screen has now become one of the standard screens used routinely at the MRC-LMB when searching initial crystallization conditions for biological macromolecules.

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Section: Discussionmentioning

confidence: 99%

The MORPHEUS protein crystallization screen

2009

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“…building blocks of functional organic compounds such as liquid crystals and electric materials (Su et al, 2004;Ahn et al, 2003;Lorenzetti et al, 2005;Chen et al, 2005). Recently, 1,8-disubstituted naphthalenes have received much attention as unique structured aromatic core compounds, exemplified by dendron cores and supramolecular building blocks (Wang & Guen, 1995;Allen et al, 1998;Crasto & Stevens, 1998, 2002.…”

Section: Methodsmentioning

confidence: 99%

“…For related literature, see: Ahn et al (2003); Allen et al (1998); Chen et al (2005); Crasto & Stevens (1998, 2002; Lorenzetti et al (2005); Nakaema et al (2007); Su et al (2004); Wang & Guen (1995). Table 1 Hydrogen-bond geometry (Å , ).…”

Section: Related Literaturementioning

confidence: 99%

2-(4-Chlorobenzoyl)-3,6-dimethoxynaphthalene

et al. 2008

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In the title compound, C19H15ClO3, the interplanar angle between the naphthalene and benzene ring systems is 62.67 (6)°. The carbonyl group is twisted from both ring planes, with torsion angles of −44.9 (2)° with respect to the naphthalene ring and −26.7 (2)° with respect to the phenylene ring. There is an intermolecular hydrogen bond between an H atom of one methoxy group and the O atom of the second methoxy group, forming chains along the ac diagonal.

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“…Other interesting examples for different medicinal applications are the use of multivalent glycomimetics such as glycodendrons as anti-inflammatory agents, antibacterial compounds, and antibiotics, and the design of dendrons specifically mimicking the endogenous interleukin 1 receptor antagonist (IL-1ra) and interleukin 8 (IL-8) . In the next section, we will describe in more detail several examples of dendrimers showing per se PPI-disruptive activity.…”

Section: Inhibition Of Protein–protein Interactions: a Concise Overviewmentioning

confidence: 99%