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Meijerink, Jocelijn; Braks, Marieta; Brack, A. A.; Adam, Wim; Dekker, Teun; Posthumus, M.A.; Beek, T.A. van; Loon, Joop J. A. van

doi:10.1023/a:1005475422978

Cited by 136 publications

(28 citation statements)

References 37 publications

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“…These alcohols were identified at small levels in incubated human sweat [9]. Only nonanol has been demonstrated as relatively attractive to Aedes aegypti (Linnaeus) compared with a control [10].…”

Section: Resultsmentioning

confidence: 99%

A laboratory evaluation of alcohols as attractants for the sandfly Lutzomyia longipalpis (Diptera:Psychodidae)

et al. 2014

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BackgroundThe potential attraction from 1-octen-3-ol for sandflies has been documented; however, studies using other primary alcohols are limited.FindingsWe used a wind tunnel to compare the activation and attractive behaviors in male and female Lutzomyia longipalpis using 1-octen-3-ol and three additional alcohols, 1-octanol, 1-heptanol and 1-nonanol at three different concentrations: neat (100%) and diluted in hexane (10% and 50%). The compounds 1-octen-3-ol and 1-nonanol induced a clear concentration-dependent activation and attraction response in females. In males, 1-octen-3-ol, 1-nonanol and 1-heptanol yielded the same results.ConclusionsL. longipalpis is attracted to 1-octen-3-ol, 1-nonanol and 1-heptanol, which are found in many plant volatiles.

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Section: Resultsmentioning

confidence: 99%

A laboratory evaluation of alcohols as attractants for the sandfly Lutzomyia longipalpis (Diptera:Psychodidae)

et al. 2014

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“…gambiae [16], though Dekker et al later showed that when the subject was lying down with the legs raised, significantly fewer mosquitoes bit the legs and feet compared to the rest of the body [15]. More recent studies suggested that body sweat was attractive [17-19] while breath had both attractant and repellent components [20]. Since nothing is known of how these different odours disperse or mix after emission by a prone human, it is impossible to draw conclusions as to which is the most important cue from the results presented here.…”

Section: Discussionmentioning

confidence: 99%

Clustering of host-seeking activity of Anopheles gambiae mosquitoes at the top surface of a human-baited bed net

Lynd

McCall

2013

Malar J

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BackgroundKnowledge of the interactions between mosquitoes and humans, and how vector control interventions affect them, is sparse. A study exploring host-seeking behaviour at a human-occupied bed net, a key event in such interactions, is reported here.MethodsHost-seeking female Anopheles gambiae activity was studied using a human-baited ‘sticky-net’ (a bed net without insecticide, coated with non-setting adhesive) to trap mosquitoes. The numbers and distribution of mosquitoes captured on each surface of the bed net were recorded and analysed using non-parametric statistical methods and random effects regression analysis. To confirm sticky-net reliability, the experiment was repeated using a pitched sticky-net (tilted sides converging at apex, i.e., neither horizontal nor vertical). The capture efficiency of horizontal and vertical sticky surfaces were compared, and the potential repellency of the adhesive was investigated.ResultsIn a semi-field experiment, more mosquitoes were caught on the top (74-87%) than on the sides of the net (p < 0.001). In laboratory experiments, more mosquitoes were caught on the top than on the sides in human-baited tests (p < 0.001), significantly different to unbaited controls (p < 0.001) where most mosquitoes were on the sides (p = 0.047). In both experiments, approximately 70% of mosquitoes captured on the top surface were clustered within a 90 × 90 cm (or lesser) area directly above the head and chest (p < 0.001). In pitched net tests, similar clustering occurred over the sleeper’s head and chest in baited tests only (p < 0.001). Capture rates at horizontal and vertical surfaces were not significantly different and the sticky-net was not repellent.ConclusionThis study demonstrated that An. gambiae activity occurs predominantly within a limited area of the top surface of bed nets. The results provide support for the two-in-one bed net design for managing pyrethroid-resistant vector populations. Further exploration of vector behaviour at the bed net interface could contribute to additional improvements in insecticide-treated bed net design or the development of novel vector control tools.

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“…to human targets. These chemical attractants include CO 2 [5], octenol [6], indole [7], ammonia [8], lactic acid and aliphatic carboxylic acids [9, 10], which are contained in human breath and sweat. The role of skin-associated microflora VOCs has also been identified as a potential source of vector attraction [11, 12].…”

Section: Introductionmentioning

confidence: 99%

Volatile organic compounds associated with Plasmodium falciparum infection in vitro

et al. 2017

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BackgroundIn order to identify new ways to prevent transmission of vector-borne diseases such as malaria, efforts have been made to understand how insects are attracted to humans. Vector-host interaction studies have shown that several volatile compounds play an important role in attracting mosquitoes to human targets. A headspace solid-phase micro-extraction/gas chromatography-mass spectrometry (HSPME GC-MS) analysis of the volatile organic composition of extracellular vesicles (EVs) and supernatants of ultracentrifugation (SNUs) was carried out in Plasmodium falciparum-infected cultures with high and low parasitemias.ResultsA list of 18 volatile organic compounds (VOCs) was obtained from the EVs of both infected and uninfected RBCs with 1,2,3-Propanetriol, diacetate (diacetin) increased in the infected EVs, regardless of the parasitemia of the culture. The supernatant analysis, however, gave off 56 VOCs, with pentane 2,2,4-trimethyl being present in all the SNUs of uninfected erythrocytes but absent from the parasite-infected ones. Standing out in this study was hexanal, a reported insect attractant, which was the only VOC present in all samples from SNUs from infected erythrocytes and absent from uninfected ones, suggesting that it originates during parasite infection.ConclusionsThe hexanal compound, reportedly a low-level component found in healthy human samples such as breath and plasma, had not been found in previous analyses of P. falciparum-infected patients or cultures. This compound has been reported as an Anopheles gambiae attractant in plants. While the compound could be produced during infection by the malaria parasite in human erythrocytes, the A. gambiae attraction could be used by the parasite as a strategy for transmission.Electronic supplementary materialThe online version of this article (doi:10.1186/s13071-017-2157-x) contains supplementary material, which is available to authorized users.

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Cited by 136 publications

References 37 publications

A laboratory evaluation of alcohols as attractants for the sandfly Lutzomyia longipalpis (Diptera:Psychodidae)

A laboratory evaluation of alcohols as attractants for the sandfly Lutzomyia longipalpis (Diptera:Psychodidae)

Clustering of host-seeking activity of Anopheles gambiae mosquitoes at the top surface of a human-baited bed net

Volatile organic compounds associated with Plasmodium falciparum infection in vitro

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