828 kHz retinal imaging with an 840 nm Fourier domain mode locked laser

Klufts, Marie; Jiménez, Alejandro Martínez; Lotz, Simon; Bashir, Muhammad Asim; Pfeiffer, Tom; Mlynek, Alexander; Wieser, Wolfgang; Chamorovskiy, Alexander; Bradu, Adrian; Podoleanu, Adrian; Huber, Robert

doi:10.1364/boe.504302

Cited by 3 publications

(1 citation statement)

References 71 publications

(81 reference statements)

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“…Since its inception, optical coherence tomography (OCT) has undergone remarkable progress, evolving from time-domain to spectral-domain configurations and, more recently, embracing the sophisticated swept-source OCT (SS-OCT) [ 1 – 3 ]. These continuous technological innovations have firmly established OCT as an indispensable tool in various biomedical imaging applications, spanning clinical fields such as ophthalmology [ 4 – 7 ], dentistry [ 8 – 12 ], dermatology [ 13 – 17 ], endoscopy [ 18 – 23 ], neuroscience [ 24 – 27 ], and more.…”

Section: Introductionmentioning

confidence: 99%

High-speed, long-range and wide-field OCT for in vivo 3D imaging of the oral cavity achieved by a 600 kHz swept source laser

Shi,

Liu,

Wang

2024

Biomed. Opt. Express

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We report a high-speed, long-range, and wide-field swept-source optical coherence tomography (SS-OCT) system aimed for imaging microstructures and microcirculations in the oral cavity. This system operates at a scan speed of 600 kHz, delivering a wide imaging field of view at 42 × 42 mm2 and a ranging distance of 36 mm. To simultaneously meet the requirements of high speed and long range, it is necessary for the k-clock trigger signal to be generated at its maximum speed, which may induce non-linear phase response in electronic devices due to the excessive k-clock frequency bandwidth, leading to phase errors. To address this challenge, we introduced a concept of electrical dispersion and a global k-clock compensation approach to improve overall performance of the imaging system. Additionally, image distortion in the wide-field imaging mode is also corrected using a method based on distortion vector maps. With this system, we demonstrate comprehensive structural and blood flow imaging of the anterior oral cavity in healthy individuals. The high-speed, long-range, and wide-field SS-OCT system opens new opportunities for comprehensive oral cavity examinations and holds promise as a reliable tool for assessing oral health conditions.

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Section: Introductionmentioning

confidence: 99%

High-speed, long-range and wide-field OCT for in vivo 3D imaging of the oral cavity achieved by a 600 kHz swept source laser

Shi,

Liu,

Wang

2024

Biomed. Opt. Express

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Downconversion Master Slave OCT With a Bidirectional Sweeping Laser

Martinez Jimenez,

Cernat,

Bradu

et al. 2024

Journal of Biophotonics

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This paper explores the challenges of signal processing when using optical coherence tomography (OCT) imaging instruments driven by asymmetric MHz bidirectional sweeping lasers. A downconversion master–slave (DMS) method is proposed as a viable alternative to the traditional OCT protocol. Unlike conventional swept source OCT, which requires a separate calibration for each sweep, the DMS approach does not require calibration of the acquired channeled spectra; its operation is independent of the tuning direction. We demonstrate the practicality of the DMS method with en‐face OCT images obtained with an OCT instrument equipped with a fast bidirectional swept laser (tuning speed 1.6 MHz) and a slow acquisition card of only 2.5 MS/s sampling rate.

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Adaptive contour-tracking to aid wide-field swept-source optical coherence tomography imaging of large objects with uneven surface topology

Liu,

Shi,

Gong

et al. 2024

Biomed. Opt. Express

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High-speed and wide-field optical coherence tomography (OCT) imaging is increasingly essential for clinical applications yet faces challenges due to its inherent sensitivity roll-off and limited depth of focus, particularly when imaging samples with significant variations in surface contour. Here, we propose one innovative solution of adaptive contour tracking and scanning methods to address these challenges. The strategy integrates an electrically tunable lens and adjustable optical delay line control with real-time surface contour information, enabling dynamic optimization of imaging protocols. It rapidly pre-scans the sample surface to acquire a comprehensive contour map. Using this map, it generates a tailored scanning protocol by partitioning the entire system ranging distance into depth-resolved segments determined by the optical Raleigh length of the objective lens, ensuring optimal imaging at each segment. Employing short-range imaging mode along the sample contour minimizes data storage and post-processing requirements, while adaptive adjustment of focal length and reference optical delay line maintains high imaging quality throughout. Experimental demonstrations show the effectiveness of the adaptive contour tracking OCT in maintaining high contrast and signal-to-noise ratio across the entire field of view, even in samples with significantly uneven surface curvatures. Notably, this approach achieves these results with reduced data volume compared to traditional OCT methods. This advancement holds promise for enhancing OCT imaging in clinical settings, particularly in applications requiring rapid, wide-field imaging of tissue structures and blood flow.

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828 kHz retinal imaging with an 840 nm Fourier domain mode locked laser

Cited by 3 publications

References 71 publications

High-speed, long-range and wide-field OCT for in vivo 3D imaging of the oral cavity achieved by a 600 kHz swept source laser

High-speed, long-range and wide-field OCT for in vivo 3D imaging of the oral cavity achieved by a 600 kHz swept source laser

Downconversion Master Slave OCT With a Bidirectional Sweeping Laser

Adaptive contour-tracking to aid wide-field swept-source optical coherence tomography imaging of large objects with uneven surface topology

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