820 Frequency and Duration Spectrum of Urologic Chronic Pelvic Pain Symptom Flares

Sutcliffe, Siobhan; Colditz, Graham A.; Pakpahan, Ratna; Song, David; Bristol, Rebecca; Gardner, Vivien; Andriole, Gerald L.; Lai, H. Henry

doi:10.1016/j.juro.2012.02.910

Cited by 1 publication

(6 citation statements)

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“…Finally, a further possible explanation is that women may have been more likely to experience flares lasting ≥1 day (as opposed to shorter flares) than men. Indeed, in our second study designed to explore the full spectrum of flares among these same participants, we found that women were more likely to report days‐long flares and less likely to report hours‐ or minutes‐long flares than men …”

Section: Discussionmentioning

confidence: 87%

“…In contrast to these participants, the remaining participants (55.0% of all participants or 45.0% of those who completed the parent study) did not complete a flare diary and were thus assumed not to have experienced a flare, although the possibility that some forgot to return their flare diary later during follow‐up cannot be ruled out. A further unexpected anecdotal finding is that some participants experienced flares lasting <1 day, which we are exploring in a separate cross‐sectional study …”

Section: Discussionmentioning

confidence: 90%

“…A further unexpected anecdotal finding is that some participants experienced flares lasting <1 day, which we are exploring in a separate cross-sectional study. 22 Comparing participants by sex, both women and men reported significantly worse symptoms by approximately 10-11 points during flares. However, women were more likely to report flares than men (70.4%, including one woman who provided information on flare days only, vs. 31.0%, P ¼ 0.0030).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, to maintain our focus on flares lasting ≥1 day, which are seen more commonly in clinical practice and are best described by a daily diary (rather than, for instance, an hourly diary), we instructed participants to complete the flare diary only when they experienced a flare lasting ≥1 day. We are exploring the full spectrum of flares from minutes to days in a separate cross‐sectional survey querying each of these durations of flares …”

Section: Methodsmentioning

confidence: 99%

“…We are exploring the full spectrum of flares from minutes to days in a separate cross-sectional survey querying each of these durations of flares. 22…”

Section: Methodsmentioning

confidence: 99%

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Changes in symptoms during urologic chronic pelvic pain syndrome symptom flares: Findings from one site of the MAPP Research Network

Sutcliffe

Colditz

Pakpahan

et al. 2013

Neurourol. Urodynam.

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Aims To provide the first description and quantification of symptom changes during interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome symptom exacerbations (“flares”). Methods Participants at one site of the Trans-Multidisciplinary Approaches to the study of chronic Pelvic Pain Epidemiology and Phenotyping Study completed two 10-day diaries over the one-year study follow-up period, one at baseline and one during their first flare (if not at baseline). On each day of the diary, participants reported whether they were currently experiencing a flare, defined as “symptoms that are much worse than usual” for at least one day, and their levels of urination-related pain, pelvic pain, urgency, and frequency on a scale of 0-10. Linear mixed models were used to calculate mean changes in symptoms between non-flare and flare days from the same participant. Results Eighteen of 27 women and 9 of 29 men reported at least one flare during follow-up, for a total of 281 non-flare and 210 flare days. Of these participants, 44.4% reported one flare, 29.6% reported two flares, and 25.9% reported ≥3 flares over the combined 20-day diary observation period, with reported flares ranging in duration from 1 day to >2 weeks. During these flares, each of the main symptoms worsened significantly by a mean of at least two points and total symptoms worsened by a mean of 11 points for both sexes (all p≤0.01). Conclusions Flares are common and correspond to a global worsening of urologic and pelvic pain symptoms.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…We are exploring the full spectrum of flares from minutes to days in a separate cross-sectional survey querying each of these durations of flares. 22…”

Section: Methodsmentioning

confidence: 99%

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