810nm near-infrared light offers neuroprotection and improves locomotor activity in MPTP-treated mice

Reinhart, Florian; Massri, Nabil El; Darlot, Fannie; Torres, Napoléon; Johnstone, Daniel M.; Chabrol, C.; Costecalde, Thomas; Stone, Jonathan; Mitrofanis, John; Benabid, Alim‐Louis; Moro, Cécile

doi:10.1016/j.neures.2014.11.005

Cited by 53 publications

(51 citation statements)

References 23 publications

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“…All devices were tested for power output using a calibrated light sensor (PM100D + S120VC; Thorlabs, Newton, NJ). The laser did not emit any measurable heat across the implant and SNc and was satisfactory for use over long periods …”

Section: Methodsmentioning

confidence: 97%

“…Three monkeys had an optical fiber implant (but not activated) into the midbrain (see below), whereas 2 were left intact. A control group exposed to NIr was not included, because we have published previously that NIr has no impact on the survival and function of cells in normal brains . Given the consistency of these results, together with the rareness of primate tissue and the ethical considerations to reduce the number of primates used, we felt that the extra control group was redundant and not justified in our study. MPTP (n = 11): monkeys were administered 1.5mg/kg MPTP over 5 days (n = 6) or 2.1mg/kg over 7 days (n = 5); 10 of these monkeys were left intact, and 1 had an optical fiber implant (not activated). MPTP‐NIr (n = 9): monkeys were administered MPTP as above, in conjunction with optical fiber implants delivering NIr over 5 (total dose of 25J; n = 5) or 7 days (total dose of 35J; n = 4).…”

Section: Methodsmentioning

confidence: 99%

“…NIr treatment has been reported to reduce cell death, increase adenosine triphosphate (ATP) content, and decrease levels of oxidative stress among cultured cells after exposure to parkinsonian toxins . Furthermore, NIr offers neuroprotection to dopaminergic cells in the well‐known 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) mouse model and in the K369I transgenic mouse model, which also shows a progressive degeneration of nigral dopaminergic cells . Together with preserving dopaminergic cell survival in these models, NIr corrects the abnormal neuronal activity generated by MPTP toxicity, as well as improving locomotor activity …”

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confidence: 99%

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Near‐infrared light is neuroprotective in a monkey model of Parkinson disease

Darlot

Moro

Massri

et al. 2015

Annals of Neurology

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Objective: To examine whether near-infrared light (NIr) treatment reduces clinical signs and/or offers neuroprotection in a subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) monkey model of Parkinson disease. Methods: We implanted an optical fiber device that delivered NIr (670nm) to the midbrain of macaque monkeys, close to the substantia nigra of both sides. MPTP injections (1.5-2.1mg/kg) were made over a 5-to 7-day period, during which time the NIr device was turned on. This was then followed by a 3-week survival period. Monkeys were evaluated clinically (eg, posture, bradykinesia) and behaviorally (open field test), and their brains were processed for immunohistochemistry and stereology. Results: All monkeys in the MPTP group developed severe clinical and behavioral impairment (mean clinical scores 5 21-34; n 5 11). By contrast, the MPTP-NIr group developed much less clinical and behavioral impairment (n 5 9); some monkeys developed moderate clinical signs (mean scores 5 11-15; n 5 3), whereas the majority-quite remarkably-developed few clinical signs (mean scores 5 1-6; n 5 6). The monkeys that developed moderate clinical signs had hematic fluid in their optical fibers at postmortem, presumably limiting NIr exposure and overall clinical improvement. NIr was not toxic to brain tissue and offered neuroprotection to dopaminergic cells and their terminations against MPTP insult, particularly in animals that developed few clinical signs. Interpretation: Our findings indicate NIr to be an effective therapeutic agent in a primate model of the disease and create the template for translation into clinical trials.

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Section: Methodsmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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Near‐infrared light is neuroprotective in a monkey model of Parkinson disease

Darlot

Moro

Massri

et al. 2015

Annals of Neurology

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“…; Reinhart et al . ), or as a result of insufficient habituation and baseline stability, since locomotor activity in the saline control group also fell between pre‐ and post‐injection trials.…”

Section: Discussionmentioning

confidence: 99%

“…We observed no significant effect of MPTP insult or saffron treatment on locomotor activity assessed by openfield test. This may have been as a result of the behavioral study being underpowered, since we have previously observed MPTP-induced OFT differences when using 10-11 mice per group (Moro et al 2013;Reinhart et al 2015), or as a result of insufficient habituation and baseline stability, since locomotor activity in the saline control group also fell between pre-and post-injection trials.…”

Section: Comparison To Previous Studies and Limitationsmentioning

confidence: 99%

Widespread brain transcriptome alterations underlie the neuroprotective actions of dietary saffron

Skladnev

Ganeshan

Kim

et al. 2016

Journal of Neurochemistry

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Dietary saffron has shown promise as a neuroprotective intervention in clinical trials of retinal degeneration and dementia and in animal models of multiple CNS disorders, including Parkinson's disease. This therapeutic potential makes it important to define the relationship between dose and protection and the mechanisms involved. To explore these two issues, mice were pre-conditioned by providing an aqueous extract of saffron (0.01% w/v) as their drinking water for 2, 5 or 10 days before administration of the parkinsonian neurotoxin MPTP (50 mg/kg). Five days of saffron pre-conditioning provided the greatest benefit against MPTP-induced neuropathology, significantly mitigating both loss of functional dopaminergic cells in the substantia nigra pars compacta (p < 0.01) and abnormal neuronal activity in the caudate-putamen complex (p < 0.0001). RNA microarray analysis of the brain transcriptome of mice pre-conditioned with saffron for 5 days revealed differential expression of 424 genes. Bioinformatics analysis identified enrichment of molecular pathways (e.g. adherens junction, TNFR1 and Fas signaling) and expression changes in candidate genes (Cyr61, Gpx8, Ndufs4, and Nos1ap) with known neuroprotective actions. The apparent biphasic nature of the dose-response relationship between saffron and measures of neuroprotection, together with the stress-inducible nature of many of the up-regulated genes and pathways, lend credence to the idea that saffron, like various other phytochemicals, is a hormetic stimulus, with functions beyond its strong antioxidant capacity. These findings provide impetus for a more comprehensive evaluation of saffron as a neuroprotective intervention.

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The Near‐Infrared Light Emitted by LiScO₂:Cr³⁺ Phosphor Used to Induce Gland Secretion for Sjogren's Syndrome

Chen,

Liu,

et al. 2024

Advanced Therapeutics

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Photobiomodulation is promisingly used as a noninvasive new weapon against Sjogren's syndrome, which is a disorder of immune system with two main symptoms of dry eyes and a dry mouth. This work reports a new NIR LED device made from LiScO2:Cr3+ phosphor for the application. The absorbance, internal, and external quantum efficiency of the optimal Li(Sc0.98Cr0.02)O2 phosphor reach 40.9%, 34.5%, and 14.1%, respectively; and the output power and energy conversion efficiency of the LED device packaged using the phosphor driven under 20 mA are 4.23 mW, respectively. The emission spectrum of the LED device can well cover the action spectrum of oxidized CuA in cytochrome c oxidase molecules. Both the pathological changes of mice submandibular gland and the expression of human submandibular gland epithelial cells (HSG) in AQP5, M3R andEGR1 confirm that the NIR light has great potential application for treating Sjogren's syndrome. Moreover, study with mice approved that the therapy using the NIR light is more efficient than the conventional medicine treatment using hydroxychloroquine sulfate.

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810nm near-infrared light offers neuroprotection and improves locomotor activity in MPTP-treated mice

Cited by 53 publications

References 23 publications

Near‐infrared light is neuroprotective in a monkey model of Parkinson disease

Near‐infrared light is neuroprotective in a monkey model of Parkinson disease

Widespread brain transcriptome alterations underlie the neuroprotective actions of dietary saffron

The Near‐Infrared Light Emitted by LiScO₂:Cr³⁺ Phosphor Used to Induce Gland Secretion for Sjogren's Syndrome

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810nm near-infrared light offers neuroprotection and improves locomotor activity in MPTP-treated mice

Cited by 53 publications

References 23 publications

Near‐infrared light is neuroprotective in a monkey model of Parkinson disease

Near‐infrared light is neuroprotective in a monkey model of Parkinson disease

Widespread brain transcriptome alterations underlie the neuroprotective actions of dietary saffron

The Near‐Infrared Light Emitted by LiScO2:Cr3+ Phosphor Used to Induce Gland Secretion for Sjogren's Syndrome

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The Near‐Infrared Light Emitted by LiScO₂:Cr³⁺ Phosphor Used to Induce Gland Secretion for Sjogren's Syndrome