800 Sustained Virologic Response to Interferon Alfa-2b Plus Ribavirin Predicts Long-Term Clearance of HCV in Pediatric Patients at 5 Year Follow-Up

Effects of pegylated interferon‐α‐2a monotherapy on growth in Japanese children with chronic hepatitis C

“…10 On the other hand, Kelly et al reported that the decrease in height percentile was most prominent in children starting treatment around the pubertal period (girls 9-12 years old, boys 11-14 years old). 12 The differences between these previous results and those in the present study are thought to have been caused by multiple factors including study sample size, and dietary and racial differences in study populations. To evaluate these complicating factors, we need a larger scale and longer term study.…”

“…In previously published studies on PEG IFN and growth from Western countries, as in the present study, bodyweight and linear growth were blunted during treatment but improved to some extent after treatment. [10][11][12] However, at a maximum of 5 years of follow up after treatment in one of these studies, the height of 97 children treated with PEG IFN-a-2b plus ribavirin (RBV) had not returned to baseline. 11 Bodyweight can be much more easily affected by dietary habits in each study population and in most studies bodyweight returned to baseline after the end of follow up.…”

“…F ROM MARCH 2005 to April 2011, 31 children (19 boys, 12 girls; median age, 6 years; range, [3][4][5][6][7][8][9][10][11][12][13][14] were treated with PEG IFN-a-2a monotherapy at our single center. They were all infected through mother-tochild transmission and were all treatment naive.…”

Five-year follow-up of patients with chronic C hepatitis and sustained virological response

“…However, few data are available in the literature about long-term follow-up after SVR is achieved, although the number of reports has increased in recent years (Table I). Sustained virological response is maintained at 5 years in 95% (4,15) and 98%-100% (10,16) of patients treated with IFN monotherapy and IFN+RBV respectively. In patients treated with Peg-IFN+RBV, SVR was maintained at 4 years in 99%-100% of cases (17)(18)(19).…”

Update der S 3-Leitlinie Prophylaxe, Diagnostik und Therapie der Hepatitis-C-Virus(HCV)-Infektion, AWMF-Register-Nr.: 021 / 012

“…Dies steht einerseits im Zusammenhang mit dem Profil der unerwünschten Wirkungen und andererseits mit der Tatsache, dass bis zu diesem Alter eine gewisse Chance auf eine spontane Viruselimination besteht. Bisherige Erfahrungen zeigen, dass die Rückfallrate bei erfolgreich behandelten Kindern mit einer persistierend negativen HCV-RNA über 6 Monate nach Abschluss der Behandlung extrem niedrig ist [729,736] [Ib].…”