“…In this work, variously substituted 3-amidocoumarins are described that exert neuroprotection in vitro against hydrogen peroxide in rat cortical neurons, as well as antioxidant activity in a1 ,1-diphenyl-2-picrylhydrazyl (DPPH·) radicals cavenging assay.S elective and reversible inhibitors of the MAO-B isoform were identified. [14] Coumarins have been found to act as antioxidants and anti-inflammatory agents, [15] neuroprotective agents, [16,17] antidepressants, [18] anticonvulsants, [19] antibacterials, [20] antivirals, [21] anticancera gents, [22,23] anticoagulants, [24] anti-hypertensives, [25] ande nzyme inhibitors, [26][27][28][29][30][31][32][33] amongo ther activities. However,t he compounds describedh erein adhere to Lipinski'sr ule of five, suggesting that this novel scaffold has desirable properties for the development of potential drug candidates.…”