8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals?
Alexander A. Kruchinin,
Polina N. Kamzeeva,
Dmitry O. Zharkov
et al.
Abstract:Numerous studies have shown that oxidative modifications of guanine (7,8-dihydro-8-oxoguanine, 8-oxoG) can affect cellular functions. 7,8-Dihydro-8-oxoadenine (8-oxoA) is another abundant paradigmatic ambiguous nucleobase but findings reported on the mutagenicity of 8-oxoA in bacterial and eukaryotic cells are incomplete and contradictory. Although several genotoxic studies have demonstrated the mutagenic potential of 8-oxoA in eukaryotic cells, very little biochemical and bioinformatics data about the mechani… Show more
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