8-Oxo-2′-deoxyguanosine ameliorates UVB-induced skin damage in hairless mice by scavenging reactive oxygen species and inhibiting MMP expression

Lee, Jin Ku; Ko, Seong Hee; Ye, Sang Kyu; Chung, Myung Hee

doi:10.1016/j.jdermsci.2013.01.010

Cited by 39 publications

(26 citation statements)

References 39 publications

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“…Furthermore, anti-inflammation agents such as COX and cytokine production inhibitors may prevent skin photodamage [ 24 , 25 , 26 ]. Accordingly, antioxidant and anti-inflammatory agents can be applied to alleviate photoaging [ 27 , 28 ]. The results of this study indicated that K36H quenches DPPH radicals and reduces UVB-induced ROS generation in Hs68 cells.…”

Section: Discussionmentioning

confidence: 99%

“…Erythema and transepidermal water loss (TEWL) were measured using an MPA 580 system (Courage + Khazaka electronic GmbH, Cologne, Germany) [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

“…The slices’ histopathology was examined using a microscope, and ImageJ software (Wayne Rasband, National Institutes of Health, Bethesda, MD, USA) was used to determine skin thickness. The samples were stained with specific monoclonal anti-mouse antibodies and examined under a microscope [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

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N-(4-bromophenethyl) Caffeamide Protects Skin from UVB-Induced Inflammation Through MAPK/IL-6/NF-κB-Dependent Signaling in Human Skin Fibroblasts and Hairless Mouse Skin

Kuo

Chen

et al. 2017

Molecules

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Long-term exposure to ultraviolet (UV) irradiation causes skin inflammation and aging. N-(4-bromophenethyl) caffeamide (K36H) possesses antioxidant and antimelanogenic properties. The present study investigated the effects of K36H on UVB-induced skin inflammation in human skin fibroblasts and hairless mice and evaluated the underlying mechanisms. The in vitro results indicated that K36H reduced UVB-induced mitogen-activated protein kinase (MAP kinase) expression. Furthermore, K36H treatment reduced cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) protein expression in UVB-irradiated fibroblasts by regulating IκB and nuclear factor-kappa B (NF-κB) expression. In the animal study, topically applied K36H markedly reduced inflammation and skin thickness and prevented photodamage to the skin of hairless mice. In addition, K36H inhibited the levels of UV-upregulated inflammation-related proteins levels such as IL-1, iNOS, and NF-κB in the dermis of hairless mice. Our findings demonstrated the antioxidant and anti-inflammatory properties of K36H in human skin fibroblasts and hairless mice. Therefore, K36H can be developed as an antiphotodamage and antiphotoinflammation agent.

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Section: Discussionmentioning

confidence: 99%

“…Erythema and transepidermal water loss (TEWL) were measured using an MPA 580 system (Courage + Khazaka electronic GmbH, Cologne, Germany) [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

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N-(4-bromophenethyl) Caffeamide Protects Skin from UVB-Induced Inflammation Through MAPK/IL-6/NF-κB-Dependent Signaling in Human Skin Fibroblasts and Hairless Mouse Skin

Kuo

Chen

et al. 2017

Molecules

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“…Вместе с ними ингибированию под-лежат ряд киназ группы MAPK (mitogen-activated protein kinase), а также наблюдается снижение кон-центрации активных форм кислорода в сравнении с контрольными клетками. А при наружном исполь-зовании 8-oxo-dG на бесшерстных мышах предот-вращается УФ-индуцированная реакция кожи [32].…”

Section: антиоксидантное и противовоспалительное действиеunclassified

Biological role of 8-oxo-2'-deoxyguanosine

Marmiy

Esipov

2015

Moscow Univ. Biol.Sci. Bull.

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The review presents currently available data on the biological role of 8-oxo-2'-deoxyguanosine. This compound has been successfully and for a long time used as a biomarker of oxidative stress and diseases associated with it. However, in recent years an increasing number of publications has appeared reporting that 8-oxo-dG is not simply a byproduct of oxidation processes, but is of great biological importance. It is assumed that it is involved in the regulation of gene expression, in some processes of DNA repair, in the control of inflammatory and autoimmune reactions, and in the activation of antioxidant systems. Probably there is a prospect of applying 8-oxo-2'-deoxyguanosine as a drug.

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“…UV exposure enhances ROS/RNS production [4,5,6], and the free radicals cause skin damage including apoptosis by interacting with DNAs, RNAs, and proteins [7]. Several lines of evidence have pointed to the implication of mitogen-activated protein kinase, aryl hydrocarbon receptor, transcription factors, such as nuclear factor-κB and nuclear factor erythroid 2-related factor 2, or matrix metalloproteinase in the degradation of dermal connective tissue following oxidative stress-induced skin damage [8,9,10,11,12,13,14,15]. …”

Section: Introductionmentioning

confidence: 99%

DCP-LA Exerts an Antiaging Action on the Skin

Nishizaki¹

2016

Skin Pharmacol Physiol

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The present study assessed the possibility for the linoleic acid derivative 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) as an antiaging compound for the skin by assaying senescence-associated β-galactosidase (SA-β-Gal), a biomarker of senescence and cell viability. The nitric oxide (NO) donor sodium nitroprusside (SNP) increased in SA-β-Gal-positive cells in cultured human fibroblasts and mouse keratinocytes, and DCP-LA significantly inhibited the effect of SNP. Moreover, SNP induced cell death in cultured mouse keratinocytes, and DCP-LA significantly prevented NO stress-induced death of keratinocytes. Taken together, these results indicate that DCP-LA exerts an antiaging action on the skin.

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8-Oxo-2′-deoxyguanosine ameliorates UVB-induced skin damage in hairless mice by scavenging reactive oxygen species and inhibiting MMP expression

Cited by 39 publications

References 39 publications

N-(4-bromophenethyl) Caffeamide Protects Skin from UVB-Induced Inflammation Through MAPK/IL-6/NF-κB-Dependent Signaling in Human Skin Fibroblasts and Hairless Mouse Skin

N-(4-bromophenethyl) Caffeamide Protects Skin from UVB-Induced Inflammation Through MAPK/IL-6/NF-κB-Dependent Signaling in Human Skin Fibroblasts and Hairless Mouse Skin

Biological role of 8-oxo-2'-deoxyguanosine

DCP-LA Exerts an Antiaging Action on the Skin

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