8-OH-DPAT suppresses vomiting in the cat elicited by motion, cisplatin or xylazine

Lucot, James B.; Crampton, George H.

doi:10.1016/0091-3057(89)90399-7

Cited by 71 publications

(19 citation statements)

References 28 publications

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“…At doses above 1000 pg/kg, SUN8399 increased the spontaneous motor activity, which lasted for 10 min. (3,5), and they further show that the effects are common to 5-HT1A-recep tor agonists and are not restricted to their effects in cats. Because subcutaneous injection of all agonists caused the serotonin syndrome, the drugs must have acted at least on the central nervous system.…”

Section: Methodsmentioning

confidence: 99%

Antiemetic Effects of Serotonergic 5-HT1A-Receptor Agonists in Suncus Murinus

Okada

Torii

Saito

et al. 1994

Japanese Journal of Pharmacology

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ABSTRACT-The antiemetic effects of six serotonergic 5-HTIA-receptor agonists, 8-hydroxy-2-(di-n-pro pylamino)tetrarin (8-OH-DPAT), 4-{4-[4-(2-pyrimidinyl)piperazin-l-yl]butyl}-2,3,4,5-tetrahydro-l,4-benzo xazepine-3,5-dione (SUN8399), buspirone, gepirone, ipsapirone and tandospirone, against motion sickness were investigated in Suncus murinus. Subcutaneous injection of all six agonists completely and dose-dependently suppressed motion-induced emesis. Pretreatment with 8-OH-DPAT or SUN8399 dose dependently inhibited emesis elicited by nicotine (4.0 mg/kg, s.c.), veratrine (0.7 mg/kg, s.c.), cisplatin (20 mg/kg, i.p.) and copper sulfate (40 mg/kg, p.o.). These results suggest that serotonergic 5-HTIA-receptor agonists are effective as anti-motion sickness drugs, and these drugs may block a common mechanism(s) for the emetic reflex of the suncus because the antiemetic effects of the 5-HT1A-receptor agonists were exerted irrespective of the stimulus.

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Section: Methodsmentioning

confidence: 99%

Antiemetic Effects of Serotonergic 5-HT1A-Receptor Agonists in Suncus Murinus

Okada

Torii

Saito

et al. 1994

Japanese Journal of Pharmacology

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“…5-HT 1A receptor agonists also block emesis induced by a variety of other pathways, such as the vomiting induced by DTG [Wolff and Leander, 1994], copper sulfate [Okada et al, 1994], xylazine, and provocative motion [Lucot and Crampton, 1989]. Furthermore, when administered chronically for periods up to 16 days, 5-HT 1A agonists such as 8-OH-DPAT [Wolff and Leander, 1994] and LY301317 (unpublished observations) maintain their ability to block emesis.…”

Section: Discussionmentioning

confidence: 93%

Pharmacological profile of LY301317, a potent and selective 5-HT1A agonist

Wolff¹,

Benvenga²,

Calligaro³

et al. 1997

Drug Dev. Res.

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“…In cats, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and buspirone suppress vomiting elicited by motion, cisplatin and xylazine (Lucot & Crampton, 1989). In Suncus, several 5-HTA receptor agonists inhibited emesis not only elicited by cisplatin but also by other stimuli (Okada et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

“…Selective antagonists for the 5-HT3 receptor inhibit emesis induced by cancer chemotherapeutic agents, such as cisplatin, in ferrets (Costall et al, 1986), dogs (Smith et al, 1986), cats (Lucot, 1989) and Suncus (Torii et al, 1991a) and these antagonists have been used clinically. It has also been reported that 5-HT,A receptor agonists can block emesis induced by motion and several emetic drugs in cats (Lucot & Crampton, 1989) and Suncus (Okada et al, 1994).…”

Section: Introduction Methodsmentioning

confidence: 99%

Blockade of motion‐ and cisplatin‐induced emesis by a 5‐HT₂ receptor agonist in Suncus murinus

Okada

Saito

Matsuki

1995

British J Pharmacology

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1 The effects of (±)-l-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), a 5-hydroxytryptamine 5-HT2A/5-HT2c receptor agonist, on motion-and cisplatin-induced emesis were studied in Suncus murinus. Subcutaneous injection of DOI, 30 min prior to the emetic stimuli, dose-dependently blocked the emesis induced by motion sickness and cisplatin (20 mg kg-', i.p.) with estimated ID50 values of 640 and 780 gg kg-1, respectively. 2 a-Methyl-5-hydroxytryptamine (t-Me-5-HT), a peripheral 5-HT2A/5-HT2c receptor agonist, had no effect on motion-and cisplatin-induced emesis. 3 The antiemetic effects of DOI on motion-and cisplatin-induced emesis were attenuated by preadministration of ketanserin, a selective 5-HT2 receptor antagonist. 4 The present results suggest an inhibitory role for central 5-HT2 receptors in the emetic reflex mechanism and that a 5-HT2 receptor agonist may be a useful tool to investigate the involvement of 5-HT receptors in the emetic reflex.

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8-OH-DPAT suppresses vomiting in the cat elicited by motion, cisplatin or xylazine

Cited by 71 publications

References 28 publications

Antiemetic Effects of Serotonergic 5-HT1A-Receptor Agonists in Suncus Murinus

Antiemetic Effects of Serotonergic 5-HT1A-Receptor Agonists in Suncus Murinus

Pharmacological profile of LY301317, a potent and selective 5-HT1A agonist

Blockade of motion‐ and cisplatin‐induced emesis by a 5‐HT₂ receptor agonist in Suncus murinus

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8-OH-DPAT suppresses vomiting in the cat elicited by motion, cisplatin or xylazine

Cited by 71 publications

References 28 publications

Antiemetic Effects of Serotonergic 5-HT1A-Receptor Agonists in Suncus Murinus

Antiemetic Effects of Serotonergic 5-HT1A-Receptor Agonists in Suncus Murinus

Pharmacological profile of LY301317, a potent and selective 5-HT1A agonist

Blockade of motion‐ and cisplatin‐induced emesis by a 5‐HT2 receptor agonist in Suncus murinus

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Blockade of motion‐ and cisplatin‐induced emesis by a 5‐HT₂ receptor agonist in Suncus murinus