8-Nitroguanine, a Potential Biomarker to Evaluate the Risk of Inflammation-Related Carcinogenesis

Ma, Ning; Murata, Mariko; Ohnishi, Shiho; Thanan, Raynoo; Hiraku, Yusuke; Kawanishi, Shosuke

doi:10.5772/36750

Cited by 3 publications

(3 citation statements)

References 76 publications

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“…Akaike et al have demonstrated that 8-nitroguanine is formed via NO production associated with inflammation in mice with viral pneumonia [ 49 ]. 8-Nitroguanine is considered to be not only a marker of inflammation, but also a potential mutagenic DNA lesion, leading to carcinogenesis [ 50 ]. 8-Nitroguanine formed in DNA is chemically unstable and thus can be spontaneously released, resulting in the formation of an apurinic site [ 51 ].…”

Section: Dna Damage In Inflammation-related Carcinogenesismentioning

confidence: 99%

DNA Damage in Inflammation-Related Carcinogenesis and Cancer Stem Cells

Ohnishi

Thanan

et al. 2013

Oxidative Medicine and Cellular Longevity

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175

138

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Infection and chronic inflammation have been recognized as important factors for carcinogenesis. Under inflammatory conditions, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from inflammatory and epithelial cells and result in oxidative and nitrative DNA damage, such as 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and 8-nitroguanine. The DNA damage can cause mutations and has been implicated in the initiation and/or promotion of inflammation-mediated carcinogenesis. It has been estimated that various infectious agents are carcinogenic to humans (IARC group 1), including parasites (Schistosoma haematobium (SH) and Opisthorchis viverrini (OV)), viruses (hepatitis C virus (HCV), human papillomavirus (HPV), and Epstein-Barr virus (EBV)), and bacterium Helicobacter pylori (HP). SH, OV, HCV, HPV, EBV, and HP are important risk factors for bladder cancer, cholangiocarcinoma, hepatocellular carcinoma, cervical cancer, nasopharyngeal carcinoma, and gastric cancer, respectively. We demonstrated that 8-nitroguanine was strongly formed via inducible nitric oxide synthase (iNOS) expression at these cancer sites of patients. Moreover, 8-nitroguanine was formed in Oct3/4-positive stem cells in SH-associated bladder cancer tissues and in Oct3/4- and CD133-positive stem cells in OV-associated cholangiocarcinoma tissues. Therefore, it is considered that oxidative and nitrative DNA damage in stem cells may play a key role in inflammation-related carcinogenesis.

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Section: Dna Damage In Inflammation-related Carcinogenesismentioning

confidence: 99%

DNA Damage in Inflammation-Related Carcinogenesis and Cancer Stem Cells

Ohnishi

Thanan

et al. 2013

Oxidative Medicine and Cellular Longevity

Self Cite

175

138

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“…•− ) tworząc nadtlenoazotyn, silnie reaktywną formę azotu, która powoduje powstanie 8-oksy-2'deoksyguanozyny oraz 8-nitroguaniny mających działanie mutagenne i mogących prowadzić do powstania nowotworu [30]. Długotrwałe uszkodzenie tkanki oznacza długi czas narażenia proliferujących komórek nabłonka i komórek zrębu na czynniki mutagenne, co dodatkowo zwiększa ryzyko rozwoju zmiany nowotworowej.…”

Section: Proces Zapalny a Nowotworzenieunclassified

Historia badań nad rolą zapalenia w onkologii

Piotrowski

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2019

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Przebieg procesu zapalnego w ciele człowieka obserwowano i opisywano już w czasach starożytnych. Wraz z rozwojem współczesnej patologii i immunologii w XIX i XX wieku zaczęto obserwować powiązania między nowotworzeniem a reakcją zapalną. Choć pierwsze doniesienia łączące ze sobą te dwa procesy datuje się na pierwszą połowę XIX wieku, to dopiero dalsze badania pozwoliły na zrozumienie oddziaływania tych procesów. Najnowsze doniesienia coraz częściej pokazują, że reakcja zapalna odgrywa bardzo ważną rolę w progresji choroby nowotworowej. Proces nowotworzenia w wielu przypadkach, jak na przykład nowotwory przewodu pokarmowego, rozpoczyna się od przewlekłego zapalenia i infekcji. Obecnie wiemy także, że reakcja zapalna często występuje w mikrośrodowisku nowotworu stymulując proliferację i migrację komórek nowotworowych. Celem tej pracy jest przybliżenie historii badań nad reakcją zapalną w nowotworzeniu, od pierwszej obserwacji tej zależności do najnowszych doniesień.

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“…8-Nitroguanine is considered to be not only a marker of inflammation, but also a potential mutagenic DNA lesion involved in carcinogenesis [19]. We have investigated the formation of 8-nitroguanine and 8-oxodG in various clinical specimens and animal models in relation to inflammation-related carcinogenesis, as summarized in Table 1.…”

Section: Dna Damage In Inflammation-related Carcinogenesismentioning

confidence: 99%

Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells

Kawanishi

Ohnishi

et al. 2017

Genes and Environ

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Infection and chronic inflammation have been recognized as important factors for carcinogenesis. Under inflammatory conditions, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from inflammatory and epithelial cells, and result in the formation of oxidative and nitrative DNA lesions, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-nitroguanine. The DNA damage can cause mutations and has been implicated in inflammation-mediated carcinogenesis. It has been estimated that various infectious agents are carcinogenic to humans (IARC group 1), including bacterium Helicobacter pylori (H. pylori), viruses [hepatitis B virus (HBV), hepatitis C virus (HCV), human papillomavirus (HPV) and Epstein-Barr virus (EBV)] and parasites [Schistosoma haematobium (SH) and Opisthorchis viverrini (OV)]. H. pylori, HBV/HCV, HPV, EBV, SH and OV are important risk factors for gastric cancer, hepatocellular carcinoma, nasopharyngeal carcinoma, bladder cancer, and cholangiocarcinoma, respectively. We demonstrated that 8-nitroguanine was strongly formed via inducible nitric oxide synthase (iNOS) expression at these cancer sites of patients. Moreover, 8-nitroguanine was formed in Oct3/4-positive stem cells in SH-associated bladder cancer tissues, and in Oct3/4-and CD133-positive stem cells in OV-associated cholangiocarcinoma tissues. Therefore, it is considered that nitrative and oxidative DNA damage in stem cells may play a key role in infection-related carcinogenesis via chronic inflammation.

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8-Nitroguanine, a Potential Biomarker to Evaluate the Risk of Inflammation-Related Carcinogenesis

Cited by 3 publications

References 76 publications

DNA Damage in Inflammation-Related Carcinogenesis and Cancer Stem Cells

DNA Damage in Inflammation-Related Carcinogenesis and Cancer Stem Cells

Historia badań nad rolą zapalenia w onkologii

Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells

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