8-methoxypsoralen and long ultraviolet effects on the rat lens: Experiments with high dosage

Koch, H.-R.; Beitzen, R.; Kremer, F.; Chioralia, G.; Baurmann, Herrad; Megaw, Judith M.; Gardner, K; Lerman, Sidney

doi:10.1007/bf02150094

Cited by 13 publications

(4 citation statements)

References 20 publications

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“…In addition to oxidizing crystallin in the nucleus of the lens these oxidants also destroy membrane integrity leading to osmotic imbalance and formation of cortical cataract. The role of oxidizing agents is supported by experimental findings 13,14 …”

Section: Age‐related Cataractmentioning

confidence: 87%

Medical treatment of cataract

Toh

Morton

Coxon

et al. 2007

Clinical Exper Ophthalmology

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The incidence of cataract continues to increase with the ageing of the population. Surgical treatment with phacoemulsification and intraocular lens implantation remains the only proven treatment. This, however, is associated with significant cost and is not readily available especially in the developing countries where the prevalence of cataract is the highest. Medical treatment of cataract is therefore a highly desired alternative. Since the last major review of medical treatment of cataract the search for an anti‐cataract agent has advanced on many fronts. Some anti‐cataract drugs, such as carnosine, have now reached clinical trials and showed encouraging results that warrant further investigation. The discovery of an effective medical treatment for cataract is likely to make global impact on eye health. The aims of this paper are to review the literature on the drug therapy of cataract and provide updates of the latest development.

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Section: Age‐related Cataractmentioning

confidence: 87%

Medical treatment of cataract

Toh

Morton

Coxon

et al. 2007

Clinical Exper Ophthalmology

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“…Results from various species, e.g. albino rats and guinea pigs showed corneal and lens opacities, whereas some other, more pigmented animals showed no alterations at all or only slight and reversible change(Cloud et al, 1961;Freeman and Troll, 1969;Parrish et al, 1979, Koch et al, 1982. It should be mentioned here that only a combined application of both psoralen and UVA was able to produce opacities; separate administration of the two factors yielded no change at all.…”

mentioning

confidence: 91%

A retrospective study of ocular findings in patients treated with PUVA

1985

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Photochemotherapy combined with psoralen, now widely used in the treatment of psoriasis, vitiligo, Andrews' disease and some other skin conditions, has been accepted as one of the potential factors that might contribute to the development of cataract. This view is based upon experimental animal studies. In the present study 408 patients receiving PUVA treatment in the period between 1977 and 1983 have been followed up for up to 6 years after the initiation of therapy. Repeated ophthalmological examinations were performed, particularly in order to detect any early signs of lens changes. In 20 patients development or increase of lens opacities could be observed. There is some evidence that in 3 of these 20 patients cataract formation was attributable to PUVA.

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“…The large doses of UVA reportedly cause cataracts in animals, and this effect is enhanced by treatments with 8-MOP. 6 Thus, ophthalmological and histopathological examinations were performed in rats treated with 8-MOP, LMFX, SPFX, or PFD. Due to the well-known sensitivity of albino rat eyes, 7 ophthalmological and histopathological evaluations of the effects of treatments on eyes were performed in LE rats with pigmented eyes.…”

Section: Introductionmentioning

confidence: 99%

Assessment of 8-Methosypsoralen, Lomefloxacin, Sparfloxacin, and Pirfenidone phototoxicity in Long-Evans Rats

Adachi¹,

Yuko²,

Satou³

et al. 2014

Int J Toxicol

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Phototoxicity has a strong impact on drug development. Although several animal models have been developed to quantitatively assess human risks, none have been validated for standardized use. In this study, we validated an in vivo phototoxicity model using Long-Evans (LE) rats treated with 4 well-known phototoxic drugs, namely 8-methoxypsoralen, lomefloxacin, sparfloxacin, and pirfenidone. Daily macroscopic observations of skin and eyes, ophthalmological examinations 4 days after dosing, and blood sampling for toxicokinetics (TKs) were performed after exposure of treated animals to ultraviolet, and dose-dependent eye and/or skin reactions were noted for all compounds. Margins of safety were calculated when possible and correlated well with known relative phototoxicity of the 4 compounds. We conclude that the present in vivo phototoxicity assay using LE rats with TK analysis can be used to quantitatively predict the risk of pharmaceutical phototoxicity in humans.

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8-methoxypsoralen and long ultraviolet effects on the rat lens: Experiments with high dosage

Cited by 13 publications

References 20 publications

Medical treatment of cataract

Medical treatment of cataract

A retrospective study of ocular findings in patients treated with PUVA

Assessment of 8-Methosypsoralen, Lomefloxacin, Sparfloxacin, and Pirfenidone phototoxicity in Long-Evans Rats

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