8-isoprostane as the main marker of oxidative stress

Herasymchuk, N. M.

doi:10.14739/2310-1210.2018.6.146780

Cited by 9 publications

(5 citation statements)

References 26 publications

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“…6,[35][36][37] The levels of 8-isoprostane are known to increase in response to oxidative stress. 38 Hence, 8-Isoprostane, which is considered as the most stable biomarker of oxidative stress was assessed in the serum of the participants enrolled in the study. 39 In the present study, participants with increased body weight and at a risk of metabolic syndrome showed a trend of increasing oxidative stress over next eight weeks.…”

Section: Discussionmentioning

confidence: 99%

Effect of SophorOx® on Oxidative Stress and Body Composition in Individuals with High BMI: A Randomized Controlled Trial

Roza,

Srivastava

2024

DMSO

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Purpose The study aimed to investigate the efficacy and safety of SophorOx ® (LN-OS-22) on oxidative stress and body composition in adults with excessive body weight and obesity. Participants and Methods The 56-days randomized, double-blind, placebo-controlled, parallel-group, multi-centric clinical trial had individuals aged 30–60 years with body mass index (BMI) ≥25 to ≤34.9 kg/m 2 . 68 participants were randomly allocated to LN-OS-22 or placebo groups. The primary outcome was improvement in the oxidative stress. Secondary outcomes were changes in plasma lipopolysaccharide (LPS) and serum malondialdehyde (MDA) levels, weight and waist circumference, inflammatory markers, and quality of life. Results At day 56, a statistically significant change in the 8-Isoprostane levels between LN-OS-22 vs placebo was observed (p = 0.0222). As compared to placebo, at the end of study, statistically significant reductions were demonstrated in body weight, waist circumference and BMI in the LN-OS-22 group (p < 0.0001). Also, a statistically significant change when compared to placebo for the energy/stamina domain (p = 0.0300) of the Impact of Weight on Quality of Life-Lite-Clinical Trials Version (IWQOL-Lite-CT) questionnaire was depicted in LN-OS-22 group. Conclusion The study demonstrates that LN-OS-22 was effective in reducing the oxidative stress, anthropometrics and improving the quality of life in individuals with overweight and obesity.

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Section: Discussionmentioning

confidence: 99%

Effect of SophorOx® on Oxidative Stress and Body Composition in Individuals with High BMI: A Randomized Controlled Trial

Roza,

Srivastava

2024

DMSO

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“…Chemically stable isoprostane detected in plasma and urine is a dependable biomarker for peroxidation induced through free radicals. 41 Research evidence suggests that it is a promising index for inflammatory disorders promoted by cyclooxygenase. 42,43 The researcher found lower in urinary 8-iso-PGF 2α content in RA patients than that of a normal individual, which was significant.…”

Section: -Isoprostanementioning

confidence: 99%

A Systematic Review on Association of Oxidative Stress in Rheumatoid Arthritis Based on Cross-Sectional Case-Control Studies

Ahmed,

Chetia,

Kalita

2024

Ind. J. Pharm. Edu. Res

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“…Oxidative stress occurs due to the increased formation of free oxygen radicals and/or weakened functioning of the antioxidant barrier [ 3 ]. An uncontrolled release of free radicals and their derivatives by damaging nucleic acids, enzymes, and biological membranes leads to the development of pathological conditions [ 5 ]. Oxygen free radicals are responsible for lipid peroxidation (LPO) [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Winter Swimming on Oxidative Stress Indicators in the Blood of Healthy Males

et al. 2023

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Baths in cold water are a popular physical activity performed to improve health. This study aimed to determine whether repeated cold-water exposure leads to the up-regulation of antioxidant defenses and whether or not this leads to a reduction in basal and/or acute pulses of oxidative distress in humans. The study group consisted of 28 healthy male members of the WS club (average age 39.3 ± 6.1 years). The study sessions occurred at the beginning and the end of the WS season. During the WS season, the participants took 3-min cold-water baths in a cold lake once a week. Blood samples were collected three times during each session: before the bath, 30 min after the bath, and 24 h after the bath. The activity of selected antioxidant enzymes, including superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx), as well as the concentration of lipid peroxidation (LPO) products, including thiobarbituric acid-reactive substances (TBARS) and conjugated dienes (CD), were determined in erythrocytes. The concentration of TBARS, CD, retinol, and α-tocopherol were determined in the blood plasma, whereas the level of other LPO products, including 4-hydroxynonenal and 8-iso-prostaglandin F2α, were determined in the blood serum. The repeated cold exposure up-regulated most antioxidant defenses, and this led to an attenuation of most indicators of oxidative stress at the baseline and acute pulses in response to cold exposure. In conclusion, due to regular cold exposure, the antioxidant barrier of winter swimmers was stimulated. Thus, short cold-bath sessions seem to be an effective intervention, inducing promoting positive adaptive changes such as the increased antioxidant capacity of the organism.

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8-isoprostane as the main marker of oxidative stress

Cited by 9 publications

References 26 publications

Effect of SophorOx® on Oxidative Stress and Body Composition in Individuals with High BMI: A Randomized Controlled Trial

Effect of SophorOx® on Oxidative Stress and Body Composition in Individuals with High BMI: A Randomized Controlled Trial

A Systematic Review on Association of Oxidative Stress in Rheumatoid Arthritis Based on Cross-Sectional Case-Control Studies

The Influence of Winter Swimming on Oxidative Stress Indicators in the Blood of Healthy Males

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