8 Improved survival with chemotherapy and radiation therapy versus radiation therapy alone in advanced nasopharyngeal cancer. Preliminary results of an intergroup randomized trial. Int 0099, SWOG 8892, RTOG 8817, ECOG 2388

Nonnasopharyngeal lymphoepithelioma of the head and neck

“…Two recently completed Phase III trials performed on patients with nasopharyngeal carcinoma are of interest. The Intergroup trial randomized patients with nasopharyngeal carcinoma to receive either radiation only or radiation given concurrently with cisplatin followed by postradiation chemotherapy 18. Forty‐two percent of the patients in the trial had LE.…”

The National Cancer Data Base Report on Cancer of the Head and Neck

“…Protocols developed to preserve the larynx, pharynx, or tongue with chemotherapy and irradiation rather than extirpative surgery have become increasingly popular over the last decade. [41][42][43][44] Whereas management of cancers at most sites with adjuvant chemotherapy has not improved cure rates, recent reports [45][46][47] indicate that the addition of adjuvant chemotherapy may offer more effective treatment for nasopharyngeal carcinoma.…”

How we wrote a landmark nasopharyngeal intergroup phase III protocol in North America

“…Because of their importance, we decided to submit these results for presentation at both of the annual meetings of the American Society for Clinical Oncology [13] and the American Society of Therapeutic Oncology [14]. This was done, and both presentations were accepted for the respective plenary sessions of the meetings in 1996 and well received.…”