8‐hydroxyquinoline and quinazoline derivatives as potential new alternatives to combat
            <i>Candida</i>
            spp. biofilm

Reginatto, Paula; Joaquim, Angélica Rocha; Rocha, Débora Assumpção; Berlitz, Simone Jacobus; Külkamp‐Guerreiro, Irene Clemes; Andrade, Saulo Fernandes de

doi:10.1111/lam.13607

Cited by 4 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have shown that indole analogues [ 52 ] and quinazoline derivatives [ 53 ] can inhibit the formation of biofilm and hyphae of C. albicans . Our findings also indicated that the structural features of diaryl chalcogenides contribute to their biological activities.…”

Section: Discussionmentioning

confidence: 99%

Anti-virulence strategy of diaryl chalcogenide compounds against Candida albicans infection

Song,

Zhao,

Sun

et al. 2023

Virulence

View full text Add to dashboard Cite

Candida albicans is an important opportunistic pathogenic fungus that frequently causes serious systemic infection in humans. Due to the vital roles of biofilm formation and the yeast-to-hypha transition in the infection process, we have selected a series of diaryl chalcogenides and tested their efficacy against C. albicans SC5314 pathogenicity by the inhibition of biofilm formation and the yeast-to-hypha transition. The compounds 5-sulfenylindole and 5-selenylindole were found to have excellent abilities to inhibit both biofilm formation and hyphal formation in C. albicans SC5314. Intriguingly, the two leading compounds also markedly attenuated C. albicans SC5314 virulence in human cell lines and mouse infection models at micromolar levels. Furthermore, our results showed that the presence of the compounds at 100 µM resulted in a marked decrease in the expression of genes involved in the cAMP-PKA and MAPK pathways in C. albicans SC5314. Intriguingly, the compounds 5-sulfenylindole and 5-selenylindole not only attenuated the cytotoxicity of Candida species strains but also showed excellent synergistic effects with antifungal agents against the clinical drug-resistant C. albicans strain HCH12. The compound 5-sulfenylindole showed an obvious advantage over fluconazole as it could also restore the composition and richness of the intestinal microbiota in mice infected by C. albicans . Together, these results suggest that diaryl chalcogenides can potentially be designed as novel clinical therapeutic agents against C. albicans infection. The diaryl chalcogenides of 5-sulfenylindole and 5-selenylindole discovered in this study can provide new direction for developing antifungal agents against C. albicans infection.

show abstract

Section: Discussionmentioning

confidence: 99%

Anti-virulence strategy of diaryl chalcogenide compounds against Candida albicans infection

Song,

Zhao,

Sun

et al. 2023

Virulence

View full text Add to dashboard Cite

show abstract

“…Its antitumor effect has mainly been associated with its ability to modulate oxidative stress, inflammation, platelet aggregation, and the induction of tumor cell apoptosis [ 11 , 12 , 13 ]. On the other hand, 8-hydroxyquinoline is a heterocyclic organic compound known to be a chelating agent with antimicrobial and anticancer activity [ 14 , 15 , 16 , 17 ]. Specifically, its anticancer activity has been associated with its possible ability to inhibit the proliferation and migration of cancer cells through the induction of apoptosis and the generation of ROS, among other mechanisms [ 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis

Bedoya-Betancur¹,

Correa²,

Rendón³

et al. 2022

Molecules

View full text Add to dashboard Cite

Seven styrylquinolines were synthesized in this study. Two of these styrylquinolines are new and were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, and normal cells (HaCaT). According to the results, compounds 3a and 3d showed antiproliferative activity in SW480 and SW620 cells, but their effect seemed to be caused by different mechanisms of action. Compound 3a induced apoptosis independent of ROS production, as evidenced by increased levels of caspase 3, and had an immunomodulatory effect, positively regulating the production of different immunological markers in malignant cell lines. In contrast, compound 3d generated a pro-oxidant response and inhibited the growth of cancer cells, probably by another type of cell death other than apoptosis. Molecular docking studies indicated that the most active compound, 3a, could efficiently bind to the proapoptotic human caspases-3 protein, a result that could provide valuable information on the biochemical mechanism for the in vitro cytotoxic response of this compound in SW620 colon carcinoma cell lines. The obtained results suggest that these compounds have chemopreventive potential against CRC, but more studies should be carried out to elucidate the molecular mechanisms of action of each of them in depth.

show abstract

Synergistic activity of clioquinol with voriconazole and amphotericin B against fungi of interest in eye infections

Reginatto,

Agostinetto,

Teixeira

et al. 2024

Journal of Medical Mycology

View full text Add to dashboard Cite

8‐hydroxyquinoline and quinazoline derivatives as potential new alternatives to combat Candida spp. biofilm

Cited by 4 publications

References 32 publications

Anti-virulence strategy of diaryl chalcogenide compounds against Candida albicans infection

Anti-virulence strategy of diaryl chalcogenide compounds against Candida albicans infection

Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis

Synergistic activity of clioquinol with voriconazole and amphotericin B against fungi of interest in eye infections

Contact Info

Product

Resources

About