1983
DOI: 10.1016/0014-2999(83)90230-3
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8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site

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Cited by 853 publications
(291 citation statements)
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“…Binding sites displaying high or low affinity for spiperone have been designated as ~-H T~A and ~-H T~B , respectively. Ligands selective for the ~-H T~A (e.g., 8-hydroxy-2-(di-n-propylamino) tetralin or 8-OH-DPAT) and 5-HT1~ subtypes (e.g., RU 24969) have been identified (Middlemiss and Fozard, 1983;Sills et al, 1984). Competition experiments in which these compounds were tested for their ability to displace [3H]-5-HT binding revealed high densities of ~-H T~A sites in the septa1 nucleus, hippocampal formation, and dorsal raphe nucleus and high densities of ~-H T~B sites in the dorsal subiculum, globus pallidus, and substantia nigra (Marcinkiewicz et al, 1984;.…”
Section: Introductionmentioning
confidence: 99%
“…Binding sites displaying high or low affinity for spiperone have been designated as ~-H T~A and ~-H T~B , respectively. Ligands selective for the ~-H T~A (e.g., 8-hydroxy-2-(di-n-propylamino) tetralin or 8-OH-DPAT) and 5-HT1~ subtypes (e.g., RU 24969) have been identified (Middlemiss and Fozard, 1983;Sills et al, 1984). Competition experiments in which these compounds were tested for their ability to displace [3H]-5-HT binding revealed high densities of ~-H T~A sites in the septa1 nucleus, hippocampal formation, and dorsal raphe nucleus and high densities of ~-H T~B sites in the dorsal subiculum, globus pallidus, and substantia nigra (Marcinkiewicz et al, 1984;.…”
Section: Introductionmentioning
confidence: 99%
“…In addition certain 5-HT-receptor agonists have been found to bind selectively to either the 5-HTIA or 5-HTIB site. One such compound is 8-hydroxy-2-(n-dipropylamino) tetralin (8-OH-DPAT) which binds specifically to the 5-HTIA site (Middlemiss & Fozard, 1983). The piperidinyl indole derivative 5-methoxy-3- [1,2, 3,6-terahydro-4-pyridinyl]-1H indole (RU24969) has been proposed as a selective ligand for the 5-HTIB site (Sills et al, 1984;Doods et al, 1985).…”
Section: Introductionmentioning
confidence: 99%
“…Receptors for 5-hydroxytryptamine (5-HT) were subdivided into 5-HT1 and 5-HT2 based on the affinities of radioligands for brain binding sites (see Peroutka & Snyder, 1979) and the 5-HT1 binding site has been further subclassified (Middlemiss & Fozard, 1983). In the periphery, 5-HT is a potent vasoconstrictor in many vascular beds, but the constriction seems to involve two distinct receptor subtypes: contractions to 5-HT in the rabbit aorta, rat aorta, rat tail artery and dog femoral artery are mediated by 5-HT2-receptors at which ketanserin is a potent and competitive antagonist (Humphrey, 1984;Peroutka, 1984); contractions in the dog saphenous vein and human and dog basilar arteries are mediated by 5-HT1 or 5-HTI-like receptors (Peroutka, 1984;Feniuk et al, 1985).…”
Section: Introductionmentioning
confidence: 99%