8-Hydroxy-2-(di-n-propylamino)tetralin, a 5-HT1A receptor agonist, impairs performance in a passive avoidance task

Carli, Mirjana; Tranchina, Salvatore; Samanin, R.

doi:10.1016/0014-2999(92)90533-a

Cited by 73 publications

(42 citation statements)

References 26 publications

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“…In agreement with earlier reports, increases in serotonergic transmission caused either by pretraining administration of the selective 5-HT 1A receptor agonist 8-OH-DPAT (Carli et al 1992;Jackson et al 1994;Misane et al 1998a;Riekkinen 1994) or by the 5-HT releasing compound PCA (Ögren 1985b;Ögren 1986a;Santucci et al 1996) produced a dose-dependent impairment of PA retention when tested 24 h later.…”

Section: Discussionsupporting

confidence: 92%

“…First, because drug treatments were made before training, statedependency at both training and retention tests might influence subsequent retention in the aversive learning task (Overton 1978). However, state-dependency does not explain the present results, because neither the selective 5-HT 1A agonists, including 8-OH-DPAT (Carli et al 1992;Misane et al 1998a), nor PCA (Ögren 1985b;Ögren 1986a;Santucci et al 1996) when administered before both training and retention restored the retention performance to the control levels. In addition, in our previous studies, post-training administration of the 5-HT 1A agonists (Misane et al 1998a) or PCA (Ögren 1985b; Ögren 1986a) did not influence the 24-hour PA retention, showing that there is no long-term carry-over behavioral effect by the drug treatment.…”

Section: Role Of Nonspecific Factors In Pacontrasting

confidence: 76%

“…In addition, 8-OH-DPAT and PCA also induce various behavioral effects; for example, modulate both general locomotor activity (Curzon 1990;Dourish et al 1985;Evenden and Angeby-Möller 1990;Hutson and Curzon 1989;, nociceptive thresholds (Hamon et al 1990;, and elicit a characteristic behavioral syndrome (5-HT syndrome) (Berendsen et al 1989;Jacobs 1976;Tricklebank et al 1984;Trulson and Jacobs 1976). However, the present and previous analysis allow us to conclude that the inhibitory effects of 8-OH-DPAT (Carli et al 1992;Misane et al 1998a;Riekkinen 1994) or PCA (Ögren 1985b;Santucci et al 1996) on PA retention cannot be simply attributed to these "nonlearning" factors. Furthermore, the ability of PCA to affect aversive learning was completely dissociated from its motor stimulant and "hypoalgesic" action .…”

Section: Role Of Nonspecific Factors In Pamentioning

confidence: 50%

“…In view of this development, the important role of 5-HT 1A receptors in learning and memory tasks including PA was revealed. The selective 5-HT 1A agonist 8-OH-DPAT given subcutaneously (SC) before PA training has consistently been found to produce a dose-dependent impairment of retention in the rat when examined 24 h later (Carli et al 1992;Jackson et al 1994;Johansson et al 1988;Misane et al 1998a;Riekkinen 1994). This PA deficit is mainly attributable to stimulation of postsynaptic 5-HT 1A receptors in the brain (Misane et al 1998a).…”

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confidence: 99%

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Multiple 5-HT Receptors in Passive Avoidance Comparative Studies of p-Chloroamphetamine and 8-OH-DPAT

Misane

2000

Neuropsychopharmacology

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KEY WORDS : Passive avoidance; 5-HT receptors; 8-OH-DPAT; p-chloroamphetamine (PCA); m-chlorophenylpiperazine (mCPP); dopamineSerotonergic (5-HT) projections, arising from the midbrain raphe nuclei (Jacobs and Azmitia 1992; Vertes 1991) innervate limbic (amygdala and hippocampus) and cortical areas known to be involved in the cognition and processing of emotional events (Ambrogi Lorenzini et al. 1998;Gallagher and Chiba 1996;Heilman and Gilmore 1998;Lavond et al. 1993;Ledoux and Müller 1997;Pezzone et al. 1992).To investigate the role of the limbic and cortical 5-HT in behavior, different appproaches have been employed ranging from manipulations that result in multiple re- Received December 23, 1998; revised May 18, 1999; accepted July 13, 1999. N EUROPSYCHOPHARMACOLOGY 2000 -VOL . 22 , NO . 2 Multiple 5-HT Receptors in Passive Avoidance 169 ceptor stimulation to the selective activation of 5-HT receptor subtypes. The former approach is of particular importance, because 5-HT neurotransmission seems to operate largely via non-or extrasynaptic mode of communication, also known as volume transmission (Agnati et al. 1995;Bunin and Wightman 1998;Descarries et al. 1990;Descarries et al. 1975;Dewar et al. 1991;Jansson et al. 1998). Thus, released 5-HT can act at a distance at multiple 5-HT receptors far away from the synaptic cleft, whereas selective 5-HT agonists act on all receptors of a specific subtype.Earlier studies have shown that treatments that increase 5-HT activity in the brain, such as 5-HT-releasing compounds [p-chloroamphetamine (PCA), MDMA, and MMAI] (Marona- Lewicka et al. 1996;McNamara et al. 1995;Ögren 1985b;Romano and Harvey 1994;Santucci et al. 1996) as well as the selective 5-HT reuptake inhibitors (SSRIs) (Altman et al. 1984;Lalonde and Vikis-Freibergs 1985;Lucki and Nobler 1985;McElroy et al. 1982;Meneses and Hong 1995;Ögren 1985b) can both enhance and impair performance in aversive learning tasks. Pretraining administration of PCA has been found to produce a marked impairment of both one-and two-way active avoidance acquisition and retention in the rat (Ögren 1982).Although PCA also causes an acute release of dopamine (DA) (Crespi et al. 1997;Henderson et al. 1993;Johnson et al. 1990;Ögren 1985b;Sharp et al. 1986) as well noradrenaline (NA) (Ögren 1982; Ögren 1985a) in the rat brain, its behavioral effects are mediated primarily via serotonergic mechanisms (Adell et al. 1989;Geyer 1996;Hutson and Curzon 1989;Trulson and Jacobs 1976). In support of this, the one-way active avoidance deficit by PCA was completely blocked when the rats were pretreated with 5-HT reuptake inhibitors zimeldine and fluoxetine but not by the NA uptake inhibitor desipramine (Ögren 1982). Zimeldine also blocked the 5-HT release induced by PCA (Ögren et al. 1982). Several nonselective 5-HT 2 antagonists, which, by themselves, did not impair avoidance learning, also produced a dose-dependent blockade of the PCAinduced deficit (Ögren 1986b). This finding suggested that the impairment of active avoidance acquisit...

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Section: Discussionsupporting

confidence: 92%

Section: Role Of Nonspecific Factors In Pacontrasting

confidence: 76%

Section: Role Of Nonspecific Factors In Pamentioning

confidence: 50%

mentioning

confidence: 99%

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Multiple 5-HT Receptors in Passive Avoidance Comparative Studies of p-Chloroamphetamine and 8-OH-DPAT

Misane

2000

Neuropsychopharmacology

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“…The selective 5-HT 1A agonist 8-OH-DPAT given subcutaneously (s.c.) prior to PA training was found to produce a dose-dependent impairment of retention in the rat when examined 24 h later (Carli et al, 1992;Misane et al, 1998a;Misane and Ö gren, 2000). The PA impairment caused by 8-OH-DPAT was related to stimulation of post-but not presynaptic 5-HT 1A receptors in the brain (Misane et al, 1998a;Misane and Ö gren, 2000).…”

Section: Introductionmentioning

confidence: 91%

Selective 5-HT1A Antagonists WAY 100635 and NAD-299 Attenuate the Impairment of Passive Avoidance Caused by Scopolamine in the Rat

Misane

Ögren

2003

Neuropsychopharmacol

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Systemic administration of the muscarinic-receptor antagonists atropine and scopolamine produces cognitive deficits in humans, nonhuman primates and rodents. In humans, these deficits resemble symptoms of dementia seen in Alzheimer's disease. The passive avoidance (PA) task has been one of the most frequently used animal models for studying cholinergic mechanisms in learning and memory. The present study examined the ability of two selective 5-HT 1A receptor antagonists WAY 100635 and NAD-299 (robalzotan) and two acetylcholinesterase (AChE) inhibitors tacrine and donepezil to attenuate the impairment of PA retention caused by the nonselective muscarinic receptor antagonist scopolamine in the rat. Although demonstrating differences in their temporal kinetics, both WAY 100635 and NAD-299 attenuated the impairment of PA caused by scopolamine (0.3 mg/kg s.c.). Donepezil did not block the PA deficit caused by the 0.3 mg/kg dose of scopolamine, but it prevented the inhibitory effects of the 0.2 mg/kg dose of scopolamine. In contrast, tacrine was effective vs both the 0.2 and 0.3 mg/kg doses of scopolamine. These results indicate that (1) a functional 5-HT 1A receptor antagonism can attenuate the anterograde amnesia produced by muscarinic-receptor blockade, and (2) the AChE inhibitors tacrine and donepezil differ in their ability to modify muscarinic-receptor-mediated function in vivo. These results suggest that 5-HT 1A receptor antagonists may have a potential in the treatment of cognitive symptoms in psychopathologies characterized by reduced ACh transmission such as Alzheimer's disease.

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5‐HT_1A and NMDA receptors interact in the rat medial septum and modulate hippocampal‐dependent spatial learning

et al. 2009

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Cholinergic and GABAergic neurons in the medial septum/vertical limb of the diagonal band of Broca (MS/vDB) projecting to the hippocampus, constitute the septohippocampal projection, which is important for hippocampal-dependent learning and memory. There is also evidence for an extrinsic as well as an intrinsic glutamatergic network within the MS/vDB. GABAergic and cholinergic septohippocampal neurons express the serotonergic 5-HT(1A) receptor and most likely also glutamatergic NMDA receptors. The aim of the present study was to examine whether septal 5-HT(1A) receptors are important for hippocampal-dependent long-term memory and whether these receptors interact with glutamatergic NMDA receptor transmission in a manner important for hippocampal-dependent spatial memory. Intraseptal infusion of the 5-HT(1A) receptor agonist (R)-8-OH-DPAT (1 or 4 microg/rat) did not affect spatial learning in the water maze task but impaired emotional memory in the passive avoidance task at the higher dose tested (4 microg/rat). While intraseptal administration of (R)-8-OH-DPAT (4 microg) combined with a subthreshold dose of the NMDA receptor antagonist D-AP5 (1 microg) only marginally affected spatial acquisition, it produced a profound impairment in spatial memory. In conclusion, septal 5-HT(1A) receptors appears to play a more prominent role in emotional than in spatial memory. Importantly, septal 5-HT(1A) and NMDA receptors appear to interact in a manner, which is particularly critical for the expression or retrieval of hippocampal-dependent long-term spatial memory. It is proposed that NMDA receptor hypofunction in the septal area may unmask a negative effect of 5-HT(1A) receptor activation on memory, which may be clinically relevant.

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8-Hydroxy-2-(di-n-propylamino)tetralin, a 5-HT1A receptor agonist, impairs performance in a passive avoidance task

Cited by 73 publications

References 26 publications

Multiple 5-HT Receptors in Passive Avoidance Comparative Studies of p-Chloroamphetamine and 8-OH-DPAT

Multiple 5-HT Receptors in Passive Avoidance Comparative Studies of p-Chloroamphetamine and 8-OH-DPAT

Selective 5-HT1A Antagonists WAY 100635 and NAD-299 Attenuate the Impairment of Passive Avoidance Caused by Scopolamine in the Rat

5‐HT_1A and NMDA receptors interact in the rat medial septum and modulate hippocampal‐dependent spatial learning

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8-Hydroxy-2-(di-n-propylamino)tetralin, a 5-HT1A receptor agonist, impairs performance in a passive avoidance task

Cited by 73 publications

References 26 publications

Multiple 5-HT Receptors in Passive Avoidance Comparative Studies of p-Chloroamphetamine and 8-OH-DPAT

Multiple 5-HT Receptors in Passive Avoidance Comparative Studies of p-Chloroamphetamine and 8-OH-DPAT

Selective 5-HT1A Antagonists WAY 100635 and NAD-299 Attenuate the Impairment of Passive Avoidance Caused by Scopolamine in the Rat

5‐HT1A and NMDA receptors interact in the rat medial septum and modulate hippocampal‐dependent spatial learning

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5‐HT_1A and NMDA receptors interact in the rat medial septum and modulate hippocampal‐dependent spatial learning