8. A partial deletion of the EP300 gene detected by microarray in an individual with mild autism

Brewer, Cheryl A.; Padeganeh, Abbas; Ghochani, Mariam; Hajianpour, Atieh; Moradian, Mike M.; Ramjit, Ruan T.

doi:10.1016/j.cancergen.2021.01.019

Cited by 1 publication

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“…There are many documents about cancer onset and autism due to mutation and partial deletion of EP300. 28,29 It seems that the activation of EP300 by EGR1 is a protective role of EGR1 against the mentioned diseases. TP53 is a well-known tumor suppressor gene.…”

Section: Discussionmentioning

confidence: 99%

EGR1 Is a Critical Gene in Response of Human Keratinocyte to Blue Light Radiation

et al. 2021

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Introduction: Investigating the molecular mechanism of cellular response to light radiation has attracted many researchers’ attention. In the present study, the critically affected gene by 7.5 min blue light radiation in human keratinocytes was investigated via network analysis. Methods: Gene expression profiles of human keratinocytes exposed to 7.5 min blue light radiation plus controls were extracted from Gene Expression Omnibus (GEO). The significant dysregulated genes plus 100 first neighbors were investigated by Cytoscape software and its applications. The central nodes of the network based on four centrality parameters were determined and discussed. Results: Among 6 significant dysregulated genes, 4 individuals were recognized by the STRING database. The network was constructed by using the 4 queried genes and 100 first neighbors. EGR1, STAT1, and ISG15 were identified as central nodes; however, the prominent role of EGR1 was highlighted. Conclusion: EGR1 appeared as a critically affected gene after blue light irradiation. It seems that this upregulated gene is responsible for protecting human keratinocytes against stress and cancer. Therefore, the application of blue light may be accompanied by antistress effects in the human body.

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Section: Discussionmentioning

confidence: 99%