7TM Receptors

Alexander, S P H; Mathie, A; Peters, J A

doi:10.1038/sj.bjp.0707753

Cited by 4 publications

(3 citation statements)

References 213 publications

(253 reference statements)

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“…A variety of mammalian GPCRs also undergo endocytosis independent of arrestin (Claing et al , 2002). Most of these, such as endothelin, muscarinic, bradykinin, cholecystokinin and thromboxane A 2 receptors, are able to activate G q proteins (Shenker et al , 1991; Hubbard and Hepler, 2006; Alexander et al , 2007). It has been shown in an in vitro system that the activity of G q protein induces endocytosis of a thromboxane A 2 β receptor (Rochdi and Parent, 2003).…”

Section: Discussionmentioning

confidence: 99%

Prolonged Gq activity triggers fly rhodopsin endocytosis and degradation, and reduces photoreceptor sensitivity

Han

Reddig

2007

EMBO J

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Rapid deactivation of the Drosophila light receptor rhodopsin, through a visual arrestin Arr2 and a pathway that involves a transcription factor dCAMTA, is required for timely termination of light responses in the photoreceptor neuron. Here we report that this process is also critical for maintenance of the photoreceptor sensitivity. In both dCAMTA- and arr2-mutant flies, the endocytosis of the major rhodopsin Rh1 was dramatically increased, which was mediated by a G(q) protein that signals downstream of rhodopsin in the visual transduction pathway. Consequently, the Rh1 level was downregulated and the photoreceptor became less sensitive to light. Remarkably, the G(q)-stimulated Rh1 endocytosis does not require phospholipase C, a known effector of G(q), but depends on a tetraspanin protein. Our work has identified an arrestin-independent endocytic pathway of G protein-coupled receptor in the fly. This pathway may also function in mammals and mediate an early feedback regulation of receptor signaling.

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Section: Discussionmentioning

confidence: 99%

Prolonged Gq activity triggers fly rhodopsin endocytosis and degradation, and reduces photoreceptor sensitivity

Han

Reddig

2007

EMBO J

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“…In iNANC signalling, VIP or NO are involved as neurotransmitters binding to the VIP receptor on ASM or interfering with the cyclic guanosine monophosphate (cGMP) pathway in ASM, respectively 1 Introduction (22; 101; 116; 178). Both, the β-receptor and the VIP-receptor belong to the family of GPCRs coupling to the G s protein (6). Upon dissociation of G s , in response to receptor stimulation, the membrane bound adenylyl cyclase becomes activated catalyzing the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP) (5; 20; 98).…”

Section: Mechanisms Of Neurally Induced Asm Relaxationmentioning

confidence: 99%

Electric field stimulation of precision-cut lung slices

Schlepütz

Uhlig

Martin

2011

Journal of Applied Physiology

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The precision-cut lung slice (PCLS) technique is widely used to examine airway responses in different species. We developed a method to study nerve-dependent bronchoconstriction by the application of electric field stimulation (EFS) to PCLS. PCLS prepared from Wistar rats were placed between two platinum electrodes to apply serial rectangular impulses (5-100 Hz), and bronchoconstriction was studied by videomicroscopy. The extent of airway contractions increased with higher frequencies. Stable repeated airway contractions were obtained at a frequency of 50 Hz, a width of 1 ms, and an output of 200 mA for 2.5 s each minute. Larger airways showed stronger responses. The EFS-triggered contractions were increased by the acetylcholine esterase inhibitor neostigmine (10 μM) and reversed by the muscarinic antagonist atropine (10 μM), whereas the thromboxane protanoid receptor antagonist SQ29548 (10 μM) had no effect. Magnesium ions (10 mM) antagonized airway contractions induced by EFS, but not by methacholine, indicating that nerve endings remain intact in PCLS. Our data further show that the electrically evoked airway contractions in PCLS are mediated by cholinergic nerves, independent of thromboxane and more prominent in larger airways. Taken together these findings show that nerve endings remain intact in PCLS, and they suggest that the present method is useful to study neurogenic responses in airways of different size.

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“…G protein-coupled receptor 137 (GPR137), also known as C11orf4, GPR137A, or TM7SF1L1 (4), is a member of cell surface mediators of signal transduction (5). GPR137 gene located in 11cen-q13.1 was originally discovered using custom search of the GenBank genomic databases based on known G protein-coupled receptor (GPCR) coding sequences (5).…”

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confidence: 99%

Knockdown of GPR137,G Protein‐coupled receptor 137, Inhibits the Proliferation and Migration of Human Prostate Cancer Cells

et al. 2016

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GPR137 belongs to the G protein-coupled receptor family involving the regulation of transmembrane signal transduction that launches pivotal cellular functions. However, its function in prostate cancer (PCa) has been rarely reported. It was found in this study that GPR137 was upregulated in PCa tissues as compared with that in paracancerous tissues. To see whether GPR137 could serve as a potential therapeutic target for PCa, GPR137 was knocked down to verify its biological function in PCa cells. Lentivirus-introduced short hairpin RNA (shRNA) was designed to silence GPR137 gene. It was found that silencing of GPR137 gene suppressed the proliferation and colony formation of PCa cell lines PC-3 and DU145. Further study indicated that growth inhibition by GPR137 knockdown was associated with cell cycle arrest at G0/G1 phase. Furthermore, silencing of GPR137 repressed the invasion and migration abilities of PC-3 cells via downregulating slug and snail and upregulating E-cadherin. Collectively, these findings imply that GPR137 plays an important role in the occurrence and progression of PCa and may prove to be a potential therapeutic target for the treatment of advanced PCa.

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7TM Receptors

Cited by 4 publications

References 213 publications

Prolonged Gq activity triggers fly rhodopsin endocytosis and degradation, and reduces photoreceptor sensitivity

Prolonged Gq activity triggers fly rhodopsin endocytosis and degradation, and reduces photoreceptor sensitivity

Electric field stimulation of precision-cut lung slices

Knockdown of GPR137,G Protein‐coupled receptor 137, Inhibits the Proliferation and Migration of Human Prostate Cancer Cells

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