78 The relationship between metabolic functions and liver histology in nonalcoholic steatohepatitis before and after treatment

Mofrad, P; Sargeant, Carol; Contos, Melissa J.; Clore, John N.; Luketic, Velimir A.; Shiffman, Mitchell A.; Sterling, Richard K.; Stravitz, R. Todd; Sanyal, Arun J.

doi:10.1016/s0270-9139(03)80121-0

Cited by 5 publications

(4 citation statements)

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“…Elevated alanine aminotransferase (ALT) has frequently been used as a biochemical surrogate for NAFLD diagnosis, however it is common to diagnose NAFLD in patients with normal ALT levels using ultrasonography or histology. [3,6] A number of biomarker-based indices have been developed to aid the diagnosis of fatty liver disease. The fatty liver index (FLI) is based on body mass index (BMI), waist circumference (WC), triglycerides (TGs), and gamma-glutamyltransferase (GGT).…”

Section: Introductionmentioning

confidence: 99%

Associations of the fatty liver and hepatic steatosis indices with risk of cardiovascular disease: Interrelationship with age

Kunutsor

Bakker

Blokzijl

et al. 2017

Clinica Chimica Acta

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Section: Introductionmentioning

confidence: 99%

Associations of the fatty liver and hepatic steatosis indices with risk of cardiovascular disease: Interrelationship with age

Kunutsor

Bakker

Blokzijl

et al. 2017

Clinica Chimica Acta

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“…Normal levels of liver transaminases have been demonstrated in several studies with the entire spectrum of NAFLD, and therefore ALT and AST activity are not supposed to be very useful in predicting NASH. [28][29][30] Current standards of normal liver enzymes were defined 2 decades ago by using general populations that may have included covert liver pathological conditions such as nonalcoholic liver disease. Prati and colleagues 31 have recently proposed a new normal upper limit of ALT for healthy males and females to be 30 U/L and 19 U/L, respectively revising the previous ones.…”

Section: Original Articlementioning

confidence: 99%

Comparative Study on Serum Hepatic Enzymes between Normal Healthy Adults and Obese People of Rajshahi City

Rashed

Jhumu

Zaman³

et al. 2022

Ibrahim card. med. j.

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Background & objective: Obesity is rapidly emerging as one of the major causes of non-alcoholic fatty liver disease (NAFLD), the early sign of which is elevated liver enzymes. But very few studies have yet been done in our country to find the association between overweight and obesity and levels of serum hepatic enzymes. The present study was undertaken to determine the association between overweight/obesity determined by body mass index (BMI) and serum hepatic enzymes. Methods: This cross-sectional analytical study was conducted in the Department of Physiology, Rajshahi Medical College, Rajshahi over a period of one year between July 2018 to June 2019 in collaboration with the Department of Biochemistry of the same Medical College. Based on certain predefined enrolment criteria, 33 overweight or obese (BMI ≥23 kg/m2) individuals (case) and 33 sex-matched apparently healthy adults (BMI <23 kg/m2) (control) were included from the Rajshahi City. All the study subjects were then tested for serum hepatic enzymes (ALT, AST, ALP and GGT). The investigation findings obtained were compared between case and control groups. Result: The mean ages of the cases and controls were almost similar (31.1 and 29.4 years respectively, p = 0.576).All the serum hepatic enzymes but GGT were found to be significantly raised in the case group than those in the control group. The BMI was found to bear significantly linear relationship with serum ALT, AST and ALP (r = 0.709, p < 0.001, r = 0.718, p < 0.001 and r = 0.545, p < 0.001 respectively) indicating that more than 70% of the variations in ALT and AST and 55% of the variations in ALP might be due to variation in BMI. When waist circumference was correlated with hepatic enzymes, it was found to correlate better than the BMI did with 70.3% of the variations in ALT, 77.2% of variations in AST and 57.4% variation in ALP being explained by waist circumference. However, WHR did not correlate well with hepatic enzymes. AST alone bears a weekly significant correlation with WHR, with only 28% of the variations in AST could be explained by WHR. Conclusion: The study concluded that all the serum hepatic enzymes but GGT are significantly raised in the overweight and obese individuals than those in individuals with normal BMI. The BMI bears significantly linear relationships with serum ALT, AST and ALP. A substantial proportion of the variations in ALT and AST could be explained by BMI. Waist circumference correlates even better than the BMI does. However, WHR is not a good predictor of serum hepatic enzymes. Ibrahim Card Med J 2021; 11 (1): 62-70

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“…They should also be helpful for the subsequent monitoring and assessment of the response to the treatment. Of note, although the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) may be elevated up to four times in MAFLD patients 8 , they can be also normal or minimally elevated and do not correlate with the fibrosis stage 9 . Therefore, their monitoring is not recommended for MAFLD management.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy and limitations of non-invasive tests in patients with metabolic-associated fatty liver disease

2021

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Resumen La incidencia de la enfermedad del hígado graso asociada al metabolismo (MAFLD) ha aumentado en los últimos años debido al estilo de vida actual. La biopsia de hígado sigue siendo la herramienta estándar de oro para detectar y estadificar MAFLD. Por otro lado, se están desarrollando múltiples biomarcadores y pruebas no invasivas para superar las limitaciones de la biopsia hepática, incluidos el costo y la invasividad. Las pruebas no invasivas se centran principalmente en la esteatosis y, en particular, en la fibrosis hepática y se pueden clasificar en pruebas patentadas y no patentadas. Si bien hepatic steatosis index y fatty liver index son las pruebas más comunes utilizadas para la detección de esteatosis, Hepamet Fibrosis Score, NAFLD fibrosis score, FIB-4, OWLiver®, y ELF® son las más utilizadas para la fibrosis hepática. Sin embargo, las pruebas no invasivas también tienen limitaciones que conviene resaltar ya que sus resultados podrían verse afectados por la presencia de diabetes, obesidad o por edades extremas que podrían dar lugar a falsos positivos o negativos. Para maximizar la precisión de los tests no invasivos, se han propuesto diferentes combinaciones integradas en algoritmos escalonados. Esta revisión tiene como objetivo destacar las fortalezas y limitaciones de dichos tests para detectar y estadificar MAFLD.

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78 The relationship between metabolic functions and liver histology in nonalcoholic steatohepatitis before and after treatment

Cited by 5 publications

References 0 publications

Associations of the fatty liver and hepatic steatosis indices with risk of cardiovascular disease: Interrelationship with age

Associations of the fatty liver and hepatic steatosis indices with risk of cardiovascular disease: Interrelationship with age

Comparative Study on Serum Hepatic Enzymes between Normal Healthy Adults and Obese People of Rajshahi City

Diagnostic accuracy and limitations of non-invasive tests in patients with metabolic-associated fatty liver disease

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