773 Differentiation Between Adenoma and Non-Adenoma in Familial Adenomatous Polyposis (FAP) Patients With Ampullary Lesion and Duodenal Polyps by Magnifying Narrow Band Imaging and Probe-Based Confocal LASER Endomicroscopy: a Pilot Study

Advances in diagnostic endoscopy for duodenal, including ampullary, adenoma

“…Our recent preliminary study using pCLE failed to show the superiority of pCLE over magnifying NBI on ampullary and non‐ampullary adenoma diagnosis in FAP patients. We reported equal accuracy at 70.4% by both systems . The diagnostic criteria for non‐adenomatous and adenomatous lesions by pCLE were normal epithelium border with regular capillary pattern and dark/irregular/non‐structural mucosa with normal or abnormal capillary networks, respectively (Fig.…”

“…This bumpy lesion can be easily recognized under both white light and NBI. Although the ‘bumpy’ lesion was very specific for adenoma it was discovered from only five lesions from a total of 12 non‐ampullary adenomas (41.6%) . The validity scores of these new criteria will be evaluated in our further study.…”

“…Although the 'bumpy' lesion was very specific for adenoma it was discovered from only five lesions from a total of 12 non-ampullary adenomas (41.6%). 30 The validity scores of these new criteria will be evaluated in our further study. Some experts described that ampullary cancer shares the same adenoma-carcinoma sequence as colon cancer pathogenesis.…”

“…We reported equal accuracy at 70.4% by both systems. 30 The diagnostic criteria for non-adenomatous and adenomatous lesions by pCLE were normal epithelium border with regular capillary pattern and dark/irregular/non-structural mucosa with normal or abnormal capillary networks, respectively ( Fig. 4).…”

“…We have found that all of the ampulla (n = 14) could be completely evaluated by using this technique and there was no need to further use the side-viewing endoscope. 30…”