762. Griseofulvin. Part IV. Structure

Grove, John Frederick; MacMillan, Jake; Mulholland, T. P. C.; Rogers, M. A. Thorold

doi:10.1039/jr9520003977

Cited by 62 publications

(22 citation statements)

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“…1) was proposed by GROVE (1952). Recently, CROSSE et al ( 1964) reported a large number of griseofulvin relatives with enhanced in vitro activity.…”

Section: Griseofulvin Floyd M Hubermentioning

confidence: 92%

Antibiotics

1967

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AII rights, especially that of tnmslation into foreign languages, reserved. It is also forbidden to reproduce this book, either whole DedicationFor most areas of scientific pursuit, there is usually that rare investigator who has the imagination to conceive ideas, who has faith in his visions, and who has the ability to critically test his concepts in the laboratory. Almost invariably, this scientist also inspires younger men to enthusiastically enter into his research program. To him should go the accolades and the recognitions of the esteem in which he is held. As only a small part of this esteem, we wish to dedicate these books to Professor SELMAN A. W AKSMAN in appreciation of his leadership and contributions in all facets of antibiotic research. PrefaceThe idea for publishing these books on the mechanism of action and on the biosynthesis of antibiotics was born of frustration in our attempts to keep abreast of the literature. Gone were the years when we were able to keep a bibliography on antibiotics and feel confident that we could find everything that was being published on this subject. These fields of investigation were moving forward so rapidly and were encompassing so wide a range of specialized areas in microbiology and chemistry that it was almost impossible to keep abreast of developments. In our naivete and enthusiasm, however, we were unaware that we were toying with an idea that might enmesh us, that we were creating an entity with a life of its own, that we were letting loose a Golom who instead of being our servant would be our master.That we set up ideals for these books is obvious; they would be current guides to developments and information in the areas of mechanism of action and biosynthesis of antibiotics. For almost every subject, we wished to enlist the aid of an investigator who himself had played a part in determining the nature of the phenomena that were being discussed. One concept for the books was that they include only antibiotics for which a definitive, well-documented mechanism of action or biosynthetic pathway was known. Yet, such an approach would not entirely serve the purpose we projected, for it would not encompass all of the information available in these fields of antibiotic investigations and blind searches for the original literature would still have to be made. We therefore chose to include any and all antibiotics about which some pertinent information had been published. It was obvious even at the start that such a compilation, integration, and analysis of information could never be complete unless scientific investigations ceased at the moment the last manuscript was submitted-an end that was neither desirable nor possible. An addendum was therefore included at the end of the volume and left open for the addition of new information until the last pages of the regular articles had been printed.The original concept has also been further expanded as the authors of several papers found it advisable to elaborate on their subject. Some of the articles included discussions...

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“…1) was proposed by GROVE (1952). Recently, CROSSE et al ( 1964) reported a large number of griseofulvin relatives with enhanced in vitro activity.…”

Section: Griseofulvin Floyd M Hubermentioning

confidence: 92%

Antibiotics

1967

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“…Griseofulvin (Fulvicin®, Grifulvin V®, Grisovin FP®, Gristatin®) was one of the first antifungal natural products discovered in filamentous fungi (Grove et al 1952). The drug is derived from the mold Penicillium griseofulvum and is commonly used to treat fungal infections of the skin, hair, and nails.…”

Section: Griseofulvinmentioning

confidence: 99%

“…Since then fungal microorganisms became a hunting ground for novel drug leads (Strobel and Daisy 2003;Larsen et al 2005). In the following years several further antimicrobial agents of fungal origin such as griseofulvin (Grove et al 1952) and cephalosporin C (Newton and Abraham 1955) were discovered. This stimulated pharmaceutical companies to sample and screen large collections of fungal strains especially for antibiotics (Butler 2004).…”

Section: Introductionmentioning

confidence: 99%

Fifty years of drug discovery from fungi

2011

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For the past 50 years, fungal secondary metabolites have revolutionized medicine yielding blockbuster drugs and drug leads of enormous therapeutic and agricultural potential. Since the discovery of penicillin, the first β-lactam antibiotic, fungi provided modern medicine with important antibiotics for curing life threatening infectious diseases. A new era in immunopharmacology and organ transplantation began with the discovery of cyclosporine. Other important drugs or products for agriculture derived from or inspired by natural products from fungi include statins, echinocandins and strobilurins. Moreover, fungal biotransformation of steroids for the industrial production of steroidal hormones represents one of the key successes in biotechnology. Given that estimations of fungal biodiversity exceed by far the number of already identified species, chances to find hitherto unidentified fungal species and novel bioactive fungal products are still high. Thus, further compounds with medicinal or agricultural potential from less investigated fungal taxa can be expected in the years to come.

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“…103 Earlier work by Grove had already identied the antifungal properties of 9 when he showed that griseofulvin and the so called 'curling factor' isolated from P. janczewskii were identical. Macmillan also reported one of the very rst examples of precursor-directed biosynthesis when he fed chloride-starved cultures of P. griseofulvum with KBr and isolated bromogriseofulvin.…”

Section: Griseofulvinmentioning

confidence: 99%

Classic fungal natural products in the genomic age: the molecular legacy of Harold Raistrick

Schor

Cox

2018

Nat. Prod. Rep.

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Harold Raistrick was involved in the discovery of many of the most important classes of fungal metabolites during the 20th century. This review focusses on how these discoveries led to developments in isotopic labelling, biomimetic chemistry and the discovery, analysis and exploitation of biosynthetic gene clusters for major classes of fungal metabolites including: alternariol; geodin and metabolites of the emodin pathway; maleidrides; citrinin and the azaphilones; dehydrocurvularin; mycophenolic acid; and the tropolones. Key recent advances in the molecular understanding of these important pathways, including the discovery of biosynthetic gene clusters, the investigation of the molecular and chemical aspects of key biosynthetic steps, and the reengineering of key components of the pathways are reviewed and compared. Finally, discussion of key relationships between metabolites and pathways and the most important recent advances and opportunities for future research directions are given.

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762. Griseofulvin. Part IV. Structure

Cited by 62 publications

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Antibiotics

Antibiotics

Fifty years of drug discovery from fungi

Classic fungal natural products in the genomic age: the molecular legacy of Harold Raistrick

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