752 Triglycerides (Tg) and Free Fatty Acids (Fea) in Enterally Fed Preterm Infants

Abstract

We have previously determined the optimal conditions for H 0 and Na absorption by the jejunum of the normal and tissue A g e d rat using various f o m l a e of oral hydration solutions (OHS). H 0 absorption was inversely pmprtional to omlality and Na &sorption was directly proportional to its concentration. In the present study we investigated the characteristics of exper-tal hydration in an animal &el of P m . This was achieved with a low protein (4%), reduced carbohydrate diet fed to juvenile rats for 3 weeks. Absorption was assessed by an in vivo perfusion procedure using an OHS with (in mEq/l) 60 Na, --0 K, 50 C1, 30 HCO and 111 Wl glucose (Glu). Phenol red and ' H 0 were used as Akers. The net H 0 fluxes in PEM (M) rats we& lower than in controls (C) (1.7$*0.10 vs 3.11f0.06 pl/min x an, Pc0.001). This difference was due both to a decrease in the mcosa-to-serosa influx of H 0 in M rats (M= 5.99f0.16; C= 6.43f0.14, Pc0.05) as w 1 1 as to2a greater efflux of fluid (M= 4.22*0.12; C; 3.52*0.13, P<0.001). PBl also resulted in failure to absorb Na from that type of 011s (M= -1.4k5.2; C= 52.2f9.4 nEq/min x an, P<O.OOl), as well as in a reduced absorption of K (M= 65.gf2.4 Data to be presented will include the complete summary analysis by gestational and postnatal age, the relationship of TG and FFA to the type, amount and method of feeding, as well as the ~ossible influence of medications. (RAP-pts) and the relationship of the pain to acid-peptic disease were investigated. The family background, medical history, family dynamics, life stress, and behavior problems of PAP-pts (n=31) were canpared using standardized questionaires to age, sex, race matched normal controls (CONI) drawn frm the schools of the patients. PAP-pts also had a physical evaluation including UGI endoscopy and a structured psychiatric interview. After evaluation, RAP-pts entered a two-month blinded, placebo-controlled (Plac) trial of cimetidine (Cine) therapy. EFFECTS OF HEMORRHAGE (H) ON THE POSTPRANDIAL REGION- 754RESULTS:RAP-pts missed more school, were more often described as unhappy, and more often had a positiue family history of peptic ulcer than CONI. The Parent's version o f the Child Behavior Checklist demonstrated internalization behavior to be significantly greater among PAP-pts than CENT. They did not differ with regard to attitudes tward school, other b w e l cmplaints, pain in other body parts, life events in the last year, family dynamics, social cunpetence, or behavior problems. Major environmental stress was frequently observed in both groups. Endoscopic findings in PAP-pts varied frm normal to erythema, thickening, and nodularity, but biopsies were normal. The treatment trial demonstrated after 1 mo that 64% of Plac-and 8EZ of Cime-treated patients had )W% improvement in pain (p)0.1). Unimproved patients were given a month of Cine therapy which resulted in improvement in 415 Plac-and 1/2 Cine-treated patients.After 2 no, 20/22 patients treated with Cime (with o r without failing Plac) had )50% improvement in pain compared ...