75

Terczyńska-Dyla, Ewa; Bibert, Stéphanie; Duong, F.H.T.; Krol, Ilona; Jørgensen, Sanne; Collinet, Emilie; Kutalik, Zoltán; Aubert, Vincent; Cerny, Andreas; Kaiser, Laurent; Malinverni, Raffaele; Mangia, Alessandra; Moradpour, Darius; Müllhaupt, Beat; Negro, Francesco; Santoro, Rosanna; Semela, David; Semmo, Nasser; Heim, Markus H.; Bochud, Pierre‐Yves; Hartmann, Rune

doi:10.1016/j.cyto.2014.07.082

Cited by 1 publication

(1 citation statement)

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“…The concept that the ss469415590 ΔG allele governing IFNL4 expression constitutes the primary variant for impaired viral clearance is supported by the recent finding that a missense variation encoding for an altered IFNL4 protein (P70S) with an attenuated antiviral activity (fig. 1) associates with an improved prognosis for HCV-infected patients [56]. Alternatively, the genetic predisposition to encode IFNL4 might tag further functional variations.…”

Section: The Novel Ifnl4mentioning

confidence: 99%

Activation of Type I and Type III Interferons in Chronic Hepatitis C

Mihm

2015

J Innate Immun

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Infection with hepatitis C virus (HCV) results in chronic and progressive liver disease. Persistency rates add up to 85%. Despite recognition of the virus by the human host in peripheral blood and in the liver, immune response appears to be ineffective in clearing infection. The ability to spontaneously eradicate the virus as well as the outcome of infection upon therapy with human recombinant interferon-α (IFN-α) was found to correlate most closely with genetic variations within the region encoding the IFN-λ genes, as revealed by genome-wide association studies on main ethnic populations in 2009. This review summarizes the induction of type I and type III IFN genes and their effectors, the IFN-stimulated genes. It focusses on the in vivo situation in chronic HCV infection in man both in the peripheral blood compartment and in the liver. It also addresses the impact of genetic polymorphisms in the region of type III IFN genes on their activation. Finally, it discusses how antiviral drugs (i.e. IFN-α, ribavirin and the direct-acting antivirals) may complementarily control the activation of endogenous IFNs and succeed in combatting infections.

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Section: The Novel Ifnl4mentioning

confidence: 99%

Activation of Type I and Type III Interferons in Chronic Hepatitis C

Mihm

2015

J Innate Immun

View full text Add to dashboard Cite

show abstract

75

Cited by 1 publication

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Activation of Type I and Type III Interferons in Chronic Hepatitis C

Activation of Type I and Type III Interferons in Chronic Hepatitis C

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