744 Predictive value of plasma haematocrit level in early diagnosis of pre-eclampsia

Golboni, Farzaneh; Heydarpour, Sousan; Taghizadeh, Ziba; Kazemnezhad, A

doi:10.26719/2011.17.10.744

Cited by 6 publications

(5 citation statements)

References 7 publications

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“…This may, therefore, be considered as an indicator for detection of preeclampsia. 5 However, in the present study, hemoglobin and PCV did not differ significantly between the two groups; this is in agreement with two studies that reported hemoglobin and hematocrit to be poor indicators. 2,6 Conflicting results were observed in a study by Monteiro et al 1 who observed that hypertensive mothers with IUGR and IUD of fetus had significantly lower hemoglobin concentration and PCV compared with those mothers with normal fetus.…”

Section: Discussionsupporting

confidence: 93%

Role of Laboratory Investigations to Assess Maternal and Perinatal Outcome in Hypertensive Mothers

Preethi¹,

Rai

Nambiar³

et al. 2017

International Journal of Infertility &Amp; Fetal Medicine

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Introduction The aim of this study was to evaluate the relevance of routinely done laboratory parameters in women with hypertensive disorders in pregnancy. Materials and methods Hypertensive pregnant women were divided into two groups based on perinatal outcome as those with and without poor perinatal outcome. They were analyzed with various laboratory tests done at the time of diagnosis: Hematological parameters, such as hemoglobin, hematocrit, platelet count, total leukocyte count, and differential count; renal parameters, such as serum urea, creatinine, and uric acid; liver function tests; and serum lactate dehydrogenase (LDH). Coagulation parameters, such as prothrombin time, activated partial thromboplastin time, and international normalized ratio were compared between the two groups. Data were presented as mean ± standard deviation; á level of p < 0.05 was set as statistically significant. Results Among the various hematological parameters, platelet count showed statistically significant differences between hypertensives with and without perinatal mortality or morbidity (p = 0.029, p = 0.029 respectively). All renal parameters showed statistically significant differences (p ≤ 0.005). Serum aspartate aminotransferase (p = 0.034) among the liver parameters and serum LDH (p = 0.024) showed statistically significant differences between the two groups. Coagulation parameters were abnormal among patients with thrombocytopenia. Conclusion Blood pressure alone is not sufficient in monitoring women with hypertensive disorders in pregnancy. Laboratory parameters that are cost-effective and routinely done in most laboratories are significant in assessing the severity of maternal disease and the perinatal outcome. It can hence, be used to monitor hypertensive women in pregnancy. How to cite this article Preethi DS, Rai L, Nambiar MJ, Kumar P, Pai MV, Amin SV. Role of Laboratory Investigations to Assess Maternal and Perinatal Outcome in Hypertensive Mothers. Int J Infertil Fetal Med 2017;8(1):18-23.

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Section: Discussionsupporting

confidence: 93%

Role of Laboratory Investigations to Assess Maternal and Perinatal Outcome in Hypertensive Mothers

Preethi¹,

Rai

Nambiar³

et al. 2017

International Journal of Infertility &Amp; Fetal Medicine

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“…After assessed, we found that only the PT plasma level had a significantly statistical difference among TT, CT and CC groups of the two polymorphisms of IL-1β (forIL-1β-31C/T: F = 1.644, P = 0.01; for IL-1β -511T/C: F = 1.587, P = 0.016). Moreover, previous researches had indicated that hematocrit, platelet counts and indices and the Mean platelet volume (MPV) were useful as screening test for early diagnosis of PE [29]–[31]. Basing on the above results, PT level in plasma may be regarded as a marker of the genotype, which needs to be clarified by further studies.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-1β-31C/T and -511T/C Polymorphisms Were Associated with Preeclampsia in Chinese Han Population

et al. 2014

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ObjectiveThe purpose of our study is to investigate the relationship between IL-1β -31C/T (rs1143627) and -511T/C (rs16944) polymorphisms and the preeclampsia (PE), and analyze the Linkage disequilibrium (LD) and haplotype frequency of the two polymorphism loci.MethodsPolymorphisms at -31C/T and -511T/C of IL-1β were genotyped with the method of polymerase chain reaction-restriction fragment length polymorphism (PCR- RFLP) in 232 PE and 447 control subjects. Genotype and allele frequencies between case-control groups were compared by chi-square(X2) tests. Two-point LD and haplotype frequency analyses were done with the software Haploview4.2.ResultsSignificant statistical differences were found between PE and control groups regarding genotype and allele frequencies of the two polymorphisms of IL-1β (For IL-1β -31C/T: X2 = 11.478, P = 0.003; For IL-1β-511T/C: X2 = 9.687, P = 0.008). LD analysis revealed that the IL-1β -31C/T SNP was in high LD with the IL-1β-511C/T SNP(D′ = 0.92, r2 = 0.79). Both CT and TC haplotypes showed significant differences between case and control groups. Only the plasma level of Prothrombin Time had a significantly statistical difference among TT, CT and CC groups of the preeclamptic two polymorphisms of IL-1β-31C/T and -511T/C (for IL-1β-31C/T, F = 1.644, P = 0.01; F = 1.587, P = 0.016).ConclusionOur results revealed IL-1β was associated with the PE in Chinese Han population. The CT haplotype may increase the risk of PE, while haplotype TC could be considered as a protective haplotype of PE.

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“…The nature of this pathophysiologic pathway is in line with the reported increased serum concentrations of atrial natriuretic peptide ( 52 ) and copeptin/vasopressin in PE ( 53 ) and with the impaired expansion of maternal plasma volume in EPE ( 9 ). The early gestational onset of this phenomenon is also supported by the shallow, but significant, rise of serum hemoglobin concentrations and hematocrit in the first trimester of pregnancies destined to develop EPE ( 31 , 54 , 55 ) but not in those eventually leading to FGR ( 56 ). As explained above and illustrated in Figure 1 , FGR pregnancies show a normal rise of plasma volume and total body water, superimposed upon constitutionally low body water already present before conception.…”

Section: Pathways Of Maternal Low Volume Circulation In Early Onset P...mentioning

confidence: 89%

Maternal Low Volume Circulation Relates to Normotensive and Preeclamptic Fetal Growth Restriction

Gyselaers

Lees

2022

Front. Med.

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This narrative review summarizes current evidence on the association between maternal low volume circulation and poor fetal growth. Though much work has been devoted to the study of cardiac output and peripheral vascular resistance, a low intravascular volume may explain why high vascular resistance causes hypertension in women with preeclampsia (PE) that is associated with fetal growth restriction (FGR) and, at the same time, presents with normotension in FGR itself. Normotensive women with small for gestational age babies show normal gestational blood volume expansion superimposed upon a constitutionally low intravascular volume. Early onset preeclampsia (EPE; occurring before 32 weeks) is commonly associated with FGR, and poor plasma volume expandability may already be present before conception, thus preceding gestational volume expansion. Experimentally induced low plasma volume in rodents predisposes to poor fetal growth and interventions that enhance plasma volume expansion in FGR have shown beneficial effects on intrauterine fetal condition, prolongation of gestation and birth weight. This review makes the case for elevating the maternal intravascular volume with physical exercise with or without Nitric Oxide Donors in FGR and EPE, and evaluating its role as a potential target for prevention and/or management of these conditions.

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744 Predictive value of plasma haematocrit level in early diagnosis of pre-eclampsia

Cited by 6 publications

References 7 publications

Role of Laboratory Investigations to Assess Maternal and Perinatal Outcome in Hypertensive Mothers

Role of Laboratory Investigations to Assess Maternal and Perinatal Outcome in Hypertensive Mothers

Interleukin-1β-31C/T and -511T/C Polymorphisms Were Associated with Preeclampsia in Chinese Han Population

Maternal Low Volume Circulation Relates to Normotensive and Preeclamptic Fetal Growth Restriction

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