739: Can first trimester high-sensitivity C-reactive protein and Sex Hormone Binding Globulin predict the onset of gestational diabetes? A prospective study of a high risk cohort

Corcoran, Siobhan; Achamallah, Natalie; John, Onyeji; Kelleher, Grainne; Stafford, Philip; Meaney, Steve; Tully, Elizabeth; Breathnach, Fionnuala; Fergal, Malone

doi:10.1016/j.ajog.2015.10.787

Cited by 6 publications

(3 citation statements)

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“…33 In another study by Corcoran et al, 2016 reported that higher levels of CRP were significantly associated with macrosomia but hS-CRP did not demonstrate additional predictive ability for GDM. 34 Finally, following further and more comprehensive studies to assess diagnostic strength of serum CRP in pregnant women at risk of GDM, use of CRP test can be considered in pregnant women qualified for gestational diabetes risk factors, as a new, fast and reliable screening test.…”

Section: Discussionmentioning

confidence: 99%

C-reactive protein as a screening test for gestational diabetes mellitus in first-trimester of pregnancy: a prospective cohort study

Farghaly

Helmy²,

Abbas

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Background: The current study aims to determine if increased inflammation identified by increased C-reactive protein (CRP) level is associated with the subsequent development of gestational diabetes mellitus (GDM).Methods: A prospective cohort study conducted at a tertiary University Hospital included 496 booking for their antenatal care visit between 10-12 weeks of gestation. They were tested for presence of CRP in blood. All women without a history of antenatal type 1 or type 2 diabetes undergo routine GDM screening with the 50-g oral glucose-loading test (GLT) between 24 and 28 weeks 'gestation. Women whose 1-h post-loading plasma glucose level >7.8 mmol/l (>140 mg/dl) undergo a diagnostic, fasting, 100-g, 3-h oral glucose tolerance test (OGTT) within 1-2 weeks following the GLT.Results: Among these 496 women, a total of 27 women (5.4%) were diagnosed as GDM and 10 women (2.0%) were diagnosed as IGT at week 24-28. The CRP was positive and higher in the GDM diagnosed group (p=0.000) compared to those who did not develop GDM. CRP was positively correlated with diagnosis of GDM (r=0.438, p=0.012).Conclusions: There is an association between first-trimester inflammation, marked by increased CRP levels and subsequent risk of GDM.

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Section: Discussionmentioning

confidence: 99%

C-reactive protein as a screening test for gestational diabetes mellitus in first-trimester of pregnancy: a prospective cohort study

Farghaly

Helmy²,

Abbas

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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“…In the other study by Corcoran et al however, higher levels of CRP were found to be significantly associated with macrosomia but hS-CRP did not demonstrate additional predictive ability for GDM [37]. In the present study, sensitivity and specificity of CRP test were found 33.3% and 98.3%, respectively, which shows that, despite acceptable attributes, qualitative CRP test has unacceptable sensitivity in predicting gestational diabetes.…”

Section: Discussionmentioning

confidence: 39%

Diagnostic Value of C-reactive Protein in Determining of Gestational Diabetes Mellitus (GDM)

Ahi¹,

Kariman2*²,

Asl³

et al. 2016

Biosci., Biotech. Res. Asia

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This study was designed to evaluate diagnostic value of C-reactive protein in determining of gestational diabetes mellitus. The present case-control study was conducted on 60 pregnant women with GDM (case group) and 120 women with normal pregnancy (control group) referred to Ayatollah Taleghani and mahdiyeh Hospitals. The serum level of qualitative and quantitative CRP was measured and diagnostic value of CRP was determined. In this study information form was completed by interview and sampling was performed by convenience method. Data were analyzed by SPSS-17 and significance level of p<0.05 was considered. Serum CRP value in GDM and control groups was 3/ 59±3/2 and 1/44±3/3 mg/liter, respectively. Regarding to cut-off of 2/2 mg/liter, sensitivity, specificity, positive predictive value and negative predictive value of quantitative CRP were 71%, 60%, 47% and 81%, respectively in diagnosis of GDM. The under curve area was 0/70. Sensitivity, specificity, positive predictive value and negative predictive value of qualitative CRP in diagnosis of GDM was calculated 33/3%, 98/3%, 90% and 74%, respectively. It seems that measuring CRP in pregnant women with GDM risk factors can be used as a simple, new and reliable method to screen gestational diabetes mellitus.

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“…Hence, quantitative C-reactive protein level is an acceptable diabetes in pregnancy 17 . In contrast to the above, the studies by Corcoran and Korkmazer showed no association between CRP and GDM 18,19 .…”

Section: Discussionmentioning

confidence: 59%

Elevated C-Reactive Protein (CRP) during First-Trimester For Gestational Diabetes Screening

2021

PJMD

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Background: Studies investigating the impact of inflammatory factors on gestational diabetes mellitus (GDM) are extremely sparse. This study aimed to find out the association of inflammation as defined by C-reactive protein (CRP) with gestational diabetes.Methods: This prospective cohort study, conducted in Patel Hospital Karachi from September 2020 to February 2021, enrolled 172 healthy gravid women at ≤ 10 weeks of pregnancy. A structured proforma was used to record age, education, past medical and obstetric history (parity, number of miscarriages, mode of deliveries, gestational age), blood pressure, height, and weight of all patients. Serum concentration of CRP and levels >1mg/dl was considered high. Oral glucose tolerance test was performed at 24-28 weeks to diagnose GDM. Data was analysed by using SPSS and Chi-squared test was applied to compare the difference between groups with, and without diabetes and p-value ≤ 0.05 was considered significant Results: Total 93 patients had raised CRP of which 8(4.6%) developed GDM (p<0.00001). Advanced age (p=0.00042) and weight (p<0.00001) were found to be independent risk factors. It was observed that CRP levels rise with increasing weight (p=0.0095) however, parity and blood pressure had no effect on GDM development. Women who had diabetes had higher BMI (<0.00001) showing that increasing weight was an independent risk factor. The sensitivity and specificity of CRP in detecting GDM was 100% and 48.17%. Conclusion:Raised C-reactive protein levels in first trimester can lead to subsequent development of hyperglycaemia of pregnancy and thus can be considered as an easy and simple screening test for GDM.

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739: Can first trimester high-sensitivity C-reactive protein and Sex Hormone Binding Globulin predict the onset of gestational diabetes? A prospective study of a high risk cohort

Cited by 6 publications

References 0 publications

C-reactive protein as a screening test for gestational diabetes mellitus in first-trimester of pregnancy: a prospective cohort study

C-reactive protein as a screening test for gestational diabetes mellitus in first-trimester of pregnancy: a prospective cohort study

Diagnostic Value of C-reactive Protein in Determining of Gestational Diabetes Mellitus (GDM)

Elevated C-Reactive Protein (CRP) during First-Trimester For Gestational Diabetes Screening

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