“…The initial radiographic lesions, usually asymmetrical, are characterized by thickening of the soft tissues and large erosions, most frequently located in the ulnar dome, carpal bones, and the base of the metacarpals. The articular spaces are usually preserved for a long time, before destruction is caused by crystal deposits in the hyaline cartilage and synovial membrane, which lead to degeneration and ankylosis (Ludwig et al 1938, Hughes et al 1968, Case report of the Massachussetts General Hospital 1970, Larmon 1970, Watt and Middlemiss 1975, Good and Rapp 1978, Bardin and Fritz 1992, Cortet et al 1994, Resnick et al 1995. The initial carpal lesions may correspond to atraumatic aseptic osteonecrosis, initiated by osseous gouty deposits.…”