7. Immunologic lung disease

Greenberger, Paul A.

doi:10.1016/j.jaci.2007.07.039

Cited by 22 publications

(24 citation statements)

References 49 publications

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“…Rescue workers showed symptoms which resulted in the diagnosis of Reactive airway dysfunction syndrome (RADS) that includes wheezing, difficulty breathing, bronchial constriction, reduced lung volume capacity, as well as possible abnormalities in the morphology of cells lining the air passages (Greenberger, 2008). Though research is ongoing, processes responsible for decreased lung function have not yet been understood on a cellular level.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of World Trade Center dust with zinc acetate and lead oxide combinations to determine damage to human lung cells

Pattnaik¹

2013

J. Toxicol. Environ. Health Sci.

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Section: Introductionmentioning

confidence: 99%

“…Materials within the WTC dust included lead, asbestos, glass, as well as numerous aromatic ring compounds (Greenberger, 2008). The International Agency for Research on Cancer (IARC) classified Pb as possible human carcinogen (group 2B) (IARC, 1987) and inorganic Pb compounds as probable human carcinogens (group 2A) (IARC, 2006).…”

Section: Introductionmentioning

confidence: 99%

Comparison of World Trade Center dust with zinc acetate and lead oxide combinations to determine damage to human lung cells

Pattnaik¹

2013

J. Toxicol. Environ. Health Sci.

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“…Materials within the WTC dust included lead, asbestos, glass, as well as numerous aromatic ring compounds [3] . The International Agency for Research on Cancer has categorized certain heavy metals as carcinogens [2] .…”

Section: Introductionmentioning

confidence: 99%

“…Lungs respond to inhaled agents in a variety of ways. Inhaled agents may lead to constriction of air passages as well as destruction of lung tissue [3] . For example, the inhalation of nickelcontaining substances has been shown to be linked to a rise in Transforming Growth Factor Beta (TGF-B) levels, yielding morphological changes in the lung tissue.…”

Section: Introductionmentioning

confidence: 99%

“…Rescue workers assessed during a 6 month period following the incident, presented symptoms which resulted in the diagnosis of Reactive Airway Dysfunction Syndrome (RADS). Symptoms of RADS include wheezing, difficulty breathing, bronchial constriction, reduced lung volume capacity, as well as possible abnormalities in the morphology of cells lining the air passages [3] . Lung carcinomas are the leading cause of cancer deaths throughout the world [6] .…”

Section: Introductionmentioning

confidence: 99%

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Indications of Potential Toxic/Mutagenic Effects of World Trade Center Dust on Human Lung Cell Cultures

Lambroussis¹,

Soares²,

Pérez³

et al. 2009

OnLine J. of Biological Sciences

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Problem statement: Respiratory complications have been linked with exposure to dust particulates after the tragedy of September 11th, 2001 at the World Trade Center (WTC) site. Approach: The purpose of these experiments was to investigate the extent of cellular damage resulting from WTC dust exposure. Results: This research project was conducted with human lung fibroblast cells exposed to WTC dust. To determine if cell proliferation levels were affected, cultured cells were exposed to WTC dust at various concentrations in simulated physiological stress environments via decreased serum levels. Results indicated that cell proliferation levels decreased as WTC dust concentrations increased. This pattern persisted regardless of serum level. The serum concentrations used were 10% Fetal Bovine Serum (FBS), which represented a non-stressed system, with 2.5 and 1% FBS concentrations used to simulate stressed environments. Assessment for apoptosis, programmed cell death, resulted in higher than baseline levels in cells exposed to WTC dust in both MRC-5 and WI-38 human lung fibroblasts. Conclusion/Recommendations: In summary, results showed that exposure to WTC dust led to decreased cell proliferation and increased apoptosis levels. These findings evidence need for future research regarding mutagenic properties of World Trade Center dust.

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