7‐Dehydrocholesterol Encapsulated Polymeric Nanoparticles As a Radiation‐Responsive Sensitizer for Enhancing Radiation Therapy

Delahunty, Ian; Li, Jianwen; Jiang, Wen Qi; Lee, Chaebin; Yang, Xueyuan; Kumar, Anil; Li, Zhi; Zhang, Weizhong; Xie, Jin

doi:10.1002/smll.202200710

Cited by 8 publications

(4 citation statements)

References 55 publications

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“…While the incubation time and NP concentration do impact biocompatibility, cell viability did not decrease below 60% even at the highest concentration of 100 μg/mL. The improved biocompatibility upon 7-DH loading could be attributed to the drug's antioxidant activity on cells 63 due to its nonspecific release, as shown in Figure 5.…”

Section: ■ Results and Discussionmentioning

confidence: 93%

Upconverting Nanoparticles Coated with Light-Breakable Mesoporous Silica for NIR-Triggered Release of Hydrophobic Molecules

Tam,

Picchetti,

Liu

et al. 2024

ACS Appl. Mater. Interfaces

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Upconverting nanoparticles (UCNPs) doped with Yb3+ and Tm3+ are near-infrared (NIR) to ultraviolet (UV) transducers that can be used for NIR-controlled drug delivery. However, due to the low quantum yield of upconversion, high laser powers and long irradiation times are required to trigger this drug release. In this work, we report the one-step synthesis of a nanocomposite consisting of a LiYbF4:Tm3+@LiYF4 UCNP coated with mesoporous UV-breakable organosilica shells of various thicknesses. We demonstrate that a thin shell accelerates the breakage of the shell at 1 W/cm2 NIR light exposure, a laser power up to 9 times lower than that of conventional systems. When the mesopores are loaded with hydrophobic vitamin D3 precursor 7-dehydrocholesterol (7-DH), shell breakage results in subsequent cargo release. Its minimal toxicity in HeLa cells and successful internalization into the cell cytoplasm demonstrate its biocompatibility and potential application in biological systems. The tunability of this system due to its simple, one-step synthesis process and its ability to operate at low laser powers opens up avenues in UCNP-powered NIR-triggered drug delivery toward a more scalable, flexible, and ultimately translational option.

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Section: ■ Results and Discussionmentioning

confidence: 93%

Upconverting Nanoparticles Coated with Light-Breakable Mesoporous Silica for NIR-Triggered Release of Hydrophobic Molecules

Tam,

Picchetti,

Liu

et al. 2024

ACS Appl. Mater. Interfaces

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“…Compared to cells treated with ionizing radiation (IR) alone, 7-DHC@PLGA NPs associated with IR-treated cells demonstrated an increase of caspase-3 activity of 24.3% and a decreased count of all colonies formed under test radiation doses. In addition, the cell viability percentage at the dosage of two was 0.209 for 7-DHC@PLGA NPs combined with IR, whereas it was 0.530 for a single IR representing the dose-modifying factor of 2.536 ( Delahunty et al, 2022 ). Gao et al .…”

Section: Nanoparticle-based Radiosensitization Strategiesmentioning

confidence: 97%

Nanoparticle-based radiosensitization strategies for improving radiation therapy

Shen

Hong²,

Jiang³

2023

Front. Pharmacol.

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Radiotherapy remains the mainstay treatment for a variety of cancer forms. However, the therapeutic efficiency of radiation is significantly limited by several aspects, including high radiation resistance caused by low reactive oxygen species concentrations and a low absorption rate of radiation by tumor tissue, inappropriate tumor cell cycle and tumor cell apoptosis, and serious radiation damage to normal cells. In recent years, nanoparticles have been widely used as radiosensitizers due to their unique physicochemical properties and multifunctionalities for potentially enhancing radiation therapy efficacy. In this study, we systematically reviewed several nanoparticle-based radiosensitization strategies for radiation therapy use, including designing nanoparticles that upregulate the levels of reactive oxygen species, designing nanoparticles that enhance the radiation dose deposit, designing chemical drug-loaded nanoparticles for enhancing cancer cell sensitivity to radiation, designing antisense oligonucleotide gene-loaded nanoparticles, and designing nanoparticles using a unique radiation-activable property. The current challenges and opportunities for nanoparticle-based radiosensitizers are also discussed.

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“…They are converted in the liver and kidney into the active form: 1, 25-dihydroxy vitamin D (calcitriol) [5,6]. Additionally, vitamin D metabolism occurs in other tissues, and the active form serves an autocrine/paracrine function [7,8]. Serum 1, 25-dihydroxy vitamin D should be higher than 30 ng/mL [9] to maintain a healthy and normal vitamin D level.…”

Section: Introductionmentioning

confidence: 99%

Awareness of Vitamin D Deficiency among the General Population in Taif City, Saudi Arabia

AlGarni¹,

AlAmri²,

AlZahrani³

et al. 2023

Arch Pharm Pract

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Recently, vitamin D deficiency has been considered the most common nutritional deficiency all over the world that affects all age groups. The current study aimed to evaluate the level of awareness of the general population in Taif city, Saudi Arabia, toward vitamin D deficiency, vitamin D sources, and toxicity. A cross-sectional study was conducted. A validated questionnaire was distributed to the participants through social media platforms. The study included 431 participants. About half of the participants (46.6%) reported having a vitamin D deficiency history, and 13.5% of the participants were healthcare providers. Only 103 participants (23.9%) showed a good awareness level regarding vitamin D's role, sources, and toxicity. A better awareness regarding the benefits of vitamin D was indicated in females (p-value<0.001), participants with a university degree (p-value<0.001), and healthcare professionals (HCPs) (p-value<0.001). Respondents from the medical field, hold a university degree, and with a history of vitamin D deficiency had a significantly higher awareness level regarding the sources of vitamin D (p-value<0.001, p-value=0.028, and p-value=0.024, respectively). In addition, being one of the medical staff and holding a university degree were significant factors that had a favorable effect on the awareness level regarding the toxicity of vitamin D (p-value<0.001, p-value=0.009 respectively). The study demonstrated a low level of awareness among the general population toward vitamin D deficiency. Further studies are recommended to fill the awareness gap and to improve the awareness of vitamin D, its benefits, sources, and toxicity.

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7‐Dehydrocholesterol Encapsulated Polymeric Nanoparticles As a Radiation‐Responsive Sensitizer for Enhancing Radiation Therapy

Cited by 8 publications

References 55 publications

Upconverting Nanoparticles Coated with Light-Breakable Mesoporous Silica for NIR-Triggered Release of Hydrophobic Molecules

Upconverting Nanoparticles Coated with Light-Breakable Mesoporous Silica for NIR-Triggered Release of Hydrophobic Molecules

Nanoparticle-based radiosensitization strategies for improving radiation therapy

Awareness of Vitamin D Deficiency among the General Population in Taif City, Saudi Arabia

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