7, 12-dimethylbenzanthracene Tumor Induction in Mutant (hairless, Asebic, and Hairless-asebic) Mice**From the Department of Dermatology and the Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, California 94305.

Arundell, Faye D.; Karasek, Marvin A.; Gates, Allen H.

doi:10.1038/jid.1969.19

Cited by 9 publications

(1 citation statement)

References 5 publications

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“…In addition, asebia mice were later employed to study the hyperproliferative phenotype and to assess the effects of antiproliferative drugs , but they turned out to be a limited psoriasis model. Furthermore, asebia mice have been employed to study skin carcinogenesis , dermal inflammation and parasite skin penetration .…”

Section: Further Characterization and Uses Of The Asebia Mousementioning

confidence: 99%

Fifty years of the asebia mouse: origins, insights and contemporary developments

Schneider¹

2015

Experimental Dermatology

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First described as an alopecic spontaneous mutant mouse line lacking sebaceous glands in a publication in Science in 1965 by Allen H. Gates and Marvin Karasek, asebia mice soon became a popular tool for rodent sebaceous gland research. In addition to the study of sebaceous lipids, the original asebia mice and subsequent allelic mutations were widely employed to examine the influence of the sebaceous gland on hair growth, epidermal proliferation, dermal inflammation and skin carcinogenesis, among other aspects. With the identification of Scd1 gene mutations as the genetic basis of the asebia phenotype and with the advent of more refined methods for manipulating the mouse genome, asebia mice progressively lost importance. However, they contributed to, or even provided the initial spark for, several current research topics. These include the role of the sebaceous gland in hair shaft-sheath interaction and its significance for cicatricial alopecia, and the antimicrobial activity of sebum. Furthermore, mice with skin-specific deletion of SCD1, which have increased energy expenditure and are protected from high fat diet-induced obesity, provided novel insights into the crosstalk between the skin and peripheral tissues in maintaining energy homeostasis. In briefly reviewing its story, this commentary pays tribute to asebia mice and to the original publication in its golden anniversary year.

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Section: Further Characterization and Uses Of The Asebia Mousementioning

confidence: 99%

Fifty years of the asebia mouse: origins, insights and contemporary developments

Schneider¹

2015

Experimental Dermatology

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From Classical Mouse Models of Psoriasis to a Spontaneous Xenograft Model Featuring Use of AGR Mice

Nestle

Nickoloff

Animal Models of T Cell-Mediated Skin Diseases

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Studies on the role of C-type viruses in the development of epithelial tumors induced with DMBA

1975

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Epithelial tumors were induced using 0.5 per cent solution of DMBA in two strains of mice--one infected with leukoviruses (Swiss mice), and the other is free of these viruses (hairless mice). Tumors from 15 mice of each strain were examined light- and electron-microscopically. Depending on the period of administration of the carcinogen, benign growths of the type of papilloma or keratoacanthoma were obtained, or malignant tumors. In the tumors in Swiss mice electron microscopy revealed a distinct increase in the numbers of viruses in comparison with surrounding skin and intact skin of healthy mice of this strain. In spite of certain histologic differences between tumors produced in Swiss and hairless mice, the results argue against a role of leukoviruses in the pathogenesis of experimentally induced epithelial tumors in mice.

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7, 12-dimethylbenzanthracene Tumor Induction in Mutant (hairless, Asebic, and Hairless-asebic) Mice**From the Department of Dermatology and the Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, California 94305.

Cited by 9 publications

References 5 publications

Fifty years of the asebia mouse: origins, insights and contemporary developments

Fifty years of the asebia mouse: origins, insights and contemporary developments

From Classical Mouse Models of Psoriasis to a Spontaneous Xenograft Model Featuring Use of AGR Mice

Studies on the role of C-type viruses in the development of epithelial tumors induced with DMBA

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