7,10,13,16-Docosatetraenoic acid impairs neurobehavioral development by increasing reactive oxidative species production in Caenorhabditis elegans

Wu, Chia-Hsiu; Hsu, Wen-Li; Tsai, Ching-Chung; Chao, How‐Ran; Wu, Chia‐Hung; Chen, Yi‐Hsuan; Lai, Yun-Ru; Chen, Chu‐Huang; Tsai, Ming‐Hsien

doi:10.1016/j.lfs.2023.121500

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…DTA, a 2-carbon elongation product of AA, can be desaturated to generate DPAn-6 ( 62 ). Previous studies have shown that DTA can impair neurobehavioral development by increasing reactive oxidative species production in Caenorhabditis elegans ( 63 ), and higher DPAn-6 status also showed an association with worse mental health in older adults with mild cognitive impairment ( 64 ) and children and adolescents with bipolar disorder ( 65 ). The Western diet, which is high in processed foods with fat and sugar, is increasing the risk of depression ( 66 ).…”

Section: Discussionmentioning

confidence: 99%

Association between plasma polyunsaturated fatty acids and depressive among US adults

Wang,

Yan,

et al. 2024

Front. Nutr.

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BackgroundDepression is associated with greater functional impairment and high societal costs than many other mental disorders. Research on the association between plasma polyunsaturated fatty acids (PUFAs) levels and depression have yielded inconsistent results.ObjectiveTo evaluate whether plasma n-3 and n-6 PUFAs levels are associated with depression in American adults.MethodsA cross-sectional study included 2053 adults (aged ≥20 y) in the National Health and Nutrition Examination Survey (NHANES), 2011–2012. The level of plasma n-3 and n-6 PUFAs were obtained for analysis. Self-reported Patient Health Questionnaire-9 (PHQ-9) was used to identify the depression status. Binary logistic regression analysis was performed to evaluate the association between quartiles of plasma n-3 and n-6 PUFAs and depression after adjustments for confounders.ResultsThe study of 2053 respondents over 20 years of age with a weighted depression prevalence of 7.29% comprised 1,043 men (weighted proportion, 49.13%) and 1,010 women (weighted, 50.87%), with a weighted mean (SE) age of 47.58 (0.67) years. Significantly increased risks of depression over non-depression were observed in the third quartiles (OR = 1.65, 95% CI = 1.05–2.62) for arachidonic acid (AA; 20:4n-6); the third quartiles (OR = 2.20, 95% CI = 1.20–4.05) for docosatetraenoic acid (DTA; 22:4n-6); the third (OR = 2.33, 95% CI = 1.34–4.07), and highest quartiles (OR = 1.83, 95% CI = 1.03–3.26) for docosapentaenoic acid (DPAn-6; 22:5n-6); and the third (OR = 2.18, 95% CI = 1.18–4.03) and highest quartiles (OR = 2.47, 95% CI = 1.31–4.68) for docosapentaenoic acid (DPAn-3; 22:5n-3); the second (OR = 2.13, 95% CI = 1.24–3.66), third (OR = 2.40, 95% CI = 1.28–4.50), and highest quartiles (OR = 2.24, 95% CI = 1.08–4.69) for AA/docosahexaenoic acid (DHA; 22:6n-3) ratio compared with the lowest quartile after adjusting for confounding factors.ConclusionHigher plasma levels of AA, DTA, DPAn-6, DPAn-3 PUFAs, and AA/DHA ratio may be potential risk factors for depression in US adults.

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Section: Discussionmentioning

confidence: 99%

Association between plasma polyunsaturated fatty acids and depressive among US adults

Wang,

Yan,

et al. 2024

Front. Nutr.

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“…The plasma levels of omega-6 PUFA family members DGLA and adrenic acid (AdA)induced oxidative stress blocked serotonin synthesis and serotoninergic neuron activity [58].…”

Section: Discussionmentioning

confidence: 99%

Lipid Peroxidation via Regulating the Metabolism of Docosahexaenoic Acid and Arachidonic Acid in Autistic Behavioral Symptoms

Yui,

Imataka,

Shiohama

2023

CIMB

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The association between the lipid peroxidation product malondialdehyde (MDA)-modified low-density lipoprotein (MDA-LDL) and the pathophysiology of autism spectrum disorder (ASD) is unclear. This association was studied in 17 children with ASD and seven age-matched controls regarding autistic behaviors. Behavioral symptoms were assessed using the Aberrant Behavior Checklist (ABC). To compensate for the small sample size, adaptive Lasso was used to increase the likelihood of accurate prediction, and a coefficient of variation was calculated for suitable variable selection. Plasma MDA-LDL levels were significantly increased, and plasma SOD levels were significantly decreased in addition to significantly increased plasma docosahexaenoic acid (DHA) levels and significantly decreased plasma arachidonic acid (ARA) levels in the 17 subjects with ASD as compared with those of the seven healthy controls. The total ABC scores were significantly higher in the ASD group than in the control group. The results of multiple linear regression and adaptive Lasso analyses revealed an association between increased plasma DHA levels and decreased plasma ARA levels, which were significantly associated with total ABC score and increased plasma MDA-LDL levels. Therefore, an imbalance between plasma DHA and ARA levels induces ferroptosis via lipid peroxidation. Decreased levels of α-linolenic acid and γ-linolenic acid may be connected to the total ABC scores with regard to lipid peroxidation.

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Comprehensive lipidomic profiling of human milk from lactating women across varying lactation stages and gestational ages

Zhao,

Chen,

et al. 2025

Food Chemistry

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7,10,13,16-Docosatetraenoic acid impairs neurobehavioral development by increasing reactive oxidative species production in Caenorhabditis elegans

Cited by 3 publications

References 41 publications

Association between plasma polyunsaturated fatty acids and depressive among US adults

Association between plasma polyunsaturated fatty acids and depressive among US adults

Lipid Peroxidation via Regulating the Metabolism of Docosahexaenoic Acid and Arachidonic Acid in Autistic Behavioral Symptoms

Comprehensive lipidomic profiling of human milk from lactating women across varying lactation stages and gestational ages

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