7-(1,3-Dioxolan-2-ylmethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

Abstract

Key indicatorsSingle-crystal X-ray study T = 298 K Mean (C-C) = 0.005 Å R factor = 0.063 wR factor = 0.167 Data-to-parameter ratio = 12.3For details of how these key indicators were automatically derived from the article, see

Doxofyllinium tetrachloridoantimonate(III) monohydrate

“…The dihedral angle between the plane of the purine ring and the approximate plane through C4/O3/C6/O4 is 68.5°. The pure compound is 8.42° (Chen, Tu, Shu et al,2007); . In the purine ring, the bond length of N4-C11 [1.392 (3) Å] bond is somewhat longer than the corresponding N-C [1.374 (4) Å] bond length in the Chen's case .…”

“…-dione] is a therapeutic agent with anti-asthmatic (Franzone et al, 1989), anti-inflammatory activities (Zhao et al, 2001) and a bronchodilating effect on smooth muscle (Franzone et al, 1981;Villani et al, 1997). So far several organic compounds containing doxofylline have been synthesized (Chen, Tu, Shu et al,2007); Feng et al, 2007), but the doxofylline complex containing metal has not been reported. All of the above studies provide important references to futher research into doxofylline.…”

“…For related literature, see : Chen, Tu, Shu et al (2007); ; Feng et al (2007); Franzone et al (1981Franzone et al ( , 1989; Villani et al (1997); Zhao & Li (2001).…”

Solubility and Model Correlation of Doxofylline in Pure Solvents at the Temperature Range of 283.15–323.15 K

“…69975-86-6] (DFL) has a composition of C 11 H 14 N 4 O 4 and a molecular structure as shown in Figure . It is a purine alkaloid possessing pharmacological properties , and used as a therapeutic agent for its antiasthmatic and anti-inflammatory activities and a bronchodilating effect on smooth muscles. DFL has been extensively applied for controlling and managing asthma and chronic obstructive pulmonary disease. − The therapeutic mechanism of DFL is related to its ability to inhibit phosphodiesterase activity and appears to have less affinities toward adenosine A 1 and A 2 receptors, showing a better safety profile than another agent, theophylline.…”

“…has a composition of C 11 H 14 N 4 O 4 and a molecular structure as shown in Figure 1. It is a purine alkaloid possessing pharmacological properties 1,2 and used as a therapeutic agent for its antiasthmatic and anti-inflammatory activities and a bronchodilating effect on smooth muscles. DFL has been extensively applied for controlling and managing asthma and chronic obstructive pulmonary disease.…”