6α-Hydroxy-5,6-dihydrosalviasperanol

Asik, Safra Izuani Jama; Razak, Ibrahim Abdul; Salae, Abdul Wahab; Chantrapromma, Suchada; Fun, Hoong‐Kun

doi:10.1107/s160053681004208x

Cited by 2 publications

(3 citation statements)

References 6 publications

(9 reference statements)

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“…1) (Bernstein et al, 1995). The bond distances in (I) are within normal ranges (Allen et al, 1987) and comparable to the related structures (Asik et al, 2010;Razak et al, 2010).…”

Section: S1 Commentsupporting

confidence: 70%

“…For background to Verbenaceae plants and the bioactivity of icetexane, see: Bunluepuech & Tewtrakul (2009); Hymavathi et al (2009); Simmons & Sarpong (2009). For related structures, see: Asik et al (2010); Razak et al (2010). For the stability of the temperature controller used in the data collection, see Cosier & Glazer (1986).…”

Section: Related Literaturementioning

confidence: 99%

“…Premna obtusifolia (Verbenaceae), a small tree found in the mangrove forests, is one of the Verbenaceae plants. As part of our research on bioactive compounds from medicinal plants, we previouly reported the crystal structures of diterpenoids from the roots of Premna obtusifolia (Verbenaceae) which was collected from Satun province in the southern of Thailand (Asik et al, 2010;Razak et al, 2010). The title icetexane diterpenoid (I), also named as Obtusin N, is a new compound which was isolated from the same plant.…”

Section: S1 Commentmentioning

confidence: 99%

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11,12-Dihydroxy-10,6,8,11,13-icetexapentan-1-one

et al. 2011

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The title compound [systematic name: 14,15-dihydroxy-7,7-dimethyl-13-(propan-2-yl)tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),9,12,14-pentaen-4-one], C20H24O3, is a new icetexane diterpenoid which was isolated from the roots of Premna obtusifolia (Verbenaceae). The molecule has three fused rings: a cyclohexenone, a central cycloheptene and a benzene ring. The cyclohexenone ring is in an envelope conformation, whereas the cycloheptene ring is in a twisted boat conformation. Intramolecular O—H⋯O hydrogen bonds generate S(5) and S(8) ring motifs. In the crystal, molecules are linked into dimers through O—H⋯O hydrogen bonds. These dimers are arranged in to sheets parallel to the ac plane. C—H⋯O and weak C—H⋯π interactions are also present.

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“…1) (Bernstein et al, 1995). The bond distances in (I) are within normal ranges (Allen et al, 1987) and comparable to the related structures (Asik et al, 2010;Razak et al, 2010).…”

Section: S1 Commentsupporting

confidence: 70%

Section: Related Literaturementioning

confidence: 99%

Section: S1 Commentmentioning

confidence: 99%

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11,12-Dihydroxy-10,6,8,11,13-icetexapentan-1-one

et al. 2011

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Ethnomedicinal uses, phytochemistry and pharmacological aspects of the genus Premna : a review

Dianita

Jantan

2017

Pharmaceutical Biology

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Context: The genus Premna (Lamiaceae), distributed throughout tropical and subtropical Asia, Africa, Australia and the Pacific Islands, is used in folk medicine primarily to treat inflammation, immune-related diseases, stomach disorders, wound healing, and skin diseases. Objectives: This review exhaustively gathers available information on ethnopharmacological uses, phytochemistry, and bioactivity studies on more than 20 species of Premna and critically analyzes the reports to provide the perspectives and directions for future research for the plants as potential source of drug leads and pharmaceutical agents. Methods: A literature search was performed on Premna species based on books of herbal medicine, major scientific databases including Chemical Abstract, Pubmed, SciFinder, Springerlink, Science Direct, Scopus, the Web of Science, Google Scholar, and ethnobotanical databases. Results: More than 250 compounds have been isolated and identified from Premna species, comprising of diterpenoids, iridoid glycosides, and flavonoids as the most common secondary metabolites, followed by sesquiterpenes, lignans, phenylethanoids, megastigmanes, glyceroglycolipids, and ceramides. Many in vitro and in vivo studies have been conducted to evaluate the biological and pharmacological properties of the extracts, and isolated compounds of Premna species with antimicrobial, antioxidant, anti-inflammatory, immunomodulatory, antihyperglycaemia, and cytotoxic activities. Conclusion: The bioactive compounds responsible for the bioactivities of most plants have not been well identified as the reported in vivo pharmacological studies were mostly carried out on the crude extracts. The isolated bioactive components should also be further subjected to more preclinical studies and elaborate toxicity study before clinical trials can be pursued.

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6α-Hydroxy-5,6-dihydrosalviasperanol

Cited by 2 publications

References 6 publications

11,12-Dihydroxy-10,6,8,11,13-icetexapentan-1-one

11,12-Dihydroxy-10,6,8,11,13-icetexapentan-1-one

Ethnomedicinal uses, phytochemistry and pharmacological aspects of the genus Premna : a review

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