Abstract:OBJECTIVE: Male sex is associated with the development of severe neonatal opioid withdrawal syndrome (NOWS) in opioid exposed pregnancies. Placental efflux transporters, P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), are critical for transfer of drugs from the placenta to maternal circulation. Aromatase is responsible for metabolizing Methadone and Buprenorphine in the human placenta. We sought to determine whether sex differences exist in placental aromatase and efflux transporter density … Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.