695 Topical application of KPI-150, a potent inhibitor of Kv1.3 channels on effector memory T cells, demonstrates preclinical efficacy in atopic dermatitis model
“…Most infiltrating T-cells in skin lesions from patients with moderate-to-severe atopic dermatitis (AD) express high levels of Kv1.3, suggesting that inhibitors of Kv1.3 may be effective in treating AD. [72] Ovalbumininduced delayed type hypersensitivity and oxazoloneinduced dermatitis are considered to be models of atopic dermatitis. [ [81] while a topical formulation of ShK-198 was effective in treating oxazolone-induced dermatitis.…”
Section: Rat Models Of Atopic Dermatitismentioning
confidence: 99%
“…[ [81] while a topical formulation of ShK-198 was effective in treating oxazolone-induced dermatitis. [72] Even where compensation by KCa3.1 channels was reported to over-ride KV1.3 block, ShK administered alone suppressed delayed type hypersensitivity significantly in 2 of 3 studies, albeit modestly. [49]…”
Section: Rat Models Of Atopic Dermatitismentioning
“…Most infiltrating T-cells in skin lesions from patients with moderate-to-severe atopic dermatitis (AD) express high levels of Kv1.3, suggesting that inhibitors of Kv1.3 may be effective in treating AD. [72] Ovalbumininduced delayed type hypersensitivity and oxazoloneinduced dermatitis are considered to be models of atopic dermatitis. [ [81] while a topical formulation of ShK-198 was effective in treating oxazolone-induced dermatitis.…”
Section: Rat Models Of Atopic Dermatitismentioning
confidence: 99%
“…[ [81] while a topical formulation of ShK-198 was effective in treating oxazolone-induced dermatitis. [72] Even where compensation by KCa3.1 channels was reported to over-ride KV1.3 block, ShK administered alone suppressed delayed type hypersensitivity significantly in 2 of 3 studies, albeit modestly. [49]…”
Section: Rat Models Of Atopic Dermatitismentioning
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.