“…For example, acute leukaemia is characterised by the abnormal proliferation of malignant leukaemia cells in the bone marrow, leading to the suppression of normal bone marrow haematopoiesis and subsequent severe anaemia, thrombocytopenia and infection. The most typical quadruple signs are elevated blood calcium, renal insufficiency, anaemia and bone pain (2)(3). The impact of haematological malignancies on patients is obvious, especially in terms of the fatal damage to the immune system (4).…”