68Ga radiolabeled chitosan/curcumin/biotin nanocomposite as a drug carrier and early-stage cancer detection

Naeimi, Atena; Ghadi, Fereshteh Ezzati; Parizi, Zahra Pakdin; Rezakhani, Mohamad Saleh

doi:10.1016/j.ijbiomac.2023.123619

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…For instance, biotin, as a tumor-targeting agent, and curcumin, as a potential carrier of 68 Ga, were immobilized on nano-chitosan, and a novel bio-nanocomposite was designed (Chit/Cur@Biot). As shown with various in vitro studies, Chit/Cur and Chit/Cur@Biot bio-nanocomposites exhibit antitumor activity, while the Chit/Cur@Biot bio-nanocomposite is more effective than Chit/Cur against cancer cell lines at high concentrations; moreover, Chit/Cur@Biot exhibited higher cellular uptake by cancer cells [ 173 ]. Furthermore, a biotinylated cyanine derivate with a phenol group available for 131 I-labeling was developed, which showed great potential for near-infrared imaging and targeted radionuclide therapy of tumors [ 174 ].…”

Section: Further Perspectivesmentioning

confidence: 99%

Biotin Homeostasis and Human Disorders: Recent Findings and Perspectives

Karachaliou,

Livaniou

2024

IJMS

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Biotin (vitamin B7, or vitamin H) is a water-soluble B-vitamin that functions as a cofactor for carboxylases, i.e., enzymes involved in the cellular metabolism of fatty acids and amino acids and in gluconeogenesis; moreover, as reported, biotin may be involved in gene regulation. Biotin is not synthesized by human cells, but it is found in food and is also produced by intestinal bacteria. Biotin status/homeostasis in human individuals depends on several factors, including efficiency/deficiency of the enzymes involved in biotin recycling within the human organism (biotinidase, holocarboxylase synthetase), and/or effectiveness of intestinal uptake, which is mainly accomplished through the sodium-dependent multivitamin transporter. In the last years, administration of biotin at high/“pharmacological” doses has been proposed to treat specific defects/deficiencies and human disorders, exhibiting mainly neurological and/or dermatological symptoms and including biotinidase deficiency, holocarboxylase synthetase deficiency, and biotin–thiamine-responsive basal ganglia disease. On the other hand, according to warnings of the Food and Drug Administration, USA, high biotin levels can affect clinical biotin-(strept)avidin assays and thus lead to false results during quantification of critical biomarkers. In this review article, recent findings/advancements that may offer new insight in the abovementioned research fields concerning biotin will be presented and briefly discussed.

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Section: Further Perspectivesmentioning

confidence: 99%

Biotin Homeostasis and Human Disorders: Recent Findings and Perspectives

Karachaliou,

Livaniou

2024

IJMS

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Chitosan nanoparticles loaded with royal jelly: Characterization, antioxidant, antibacterial activities and in vitro digestion

Tao,

Bi,

Luo

et al. 2024

International Journal of Biological Macromolecules

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Unraveling the Chemistry of Curcumin for Colon Cancer Prevention and Treatment

Sivalingam,

Ulaganathan,

Jayakumar

et al. 2023

Multidisciplinary Applications of Natural Science for Drug Discovery and Integrative Medicine

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Colorectal cancer is the leading cause of mortality. Several studies are focused on understanding the molecular mechanism to develop potential therapeutics to enhance patient health standards. Curcumin is a bioactive component derived from Curcuma Longa implicated with a spectrum of anticancer properties such as antioxidants. It has been proposed to possess promising features in suppressing colon cancer proliferation. However, the pharmacokinetics studies denote that curcumin lacks bioavailability at the target site which leads to systemic metabolism and excretion. So, studies were diverted towards eliciting the importance of structural units and modifying curcumin conformation to improve the anti-cancer effect and bioavailability. Curcumin and its analogues were employed in clinical trials as a cotreatment group to alleviate the side effects of traditional chemotherapy. Here the authors review the recent trends in the usage of curcumin in colorectal cancer and emphasis relevant studies to update the current status of therapeutics.

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68Ga radiolabeled chitosan/curcumin/biotin nanocomposite as a drug carrier and early-stage cancer detection

Cited by 3 publications

References 42 publications

Biotin Homeostasis and Human Disorders: Recent Findings and Perspectives

Biotin Homeostasis and Human Disorders: Recent Findings and Perspectives

Chitosan nanoparticles loaded with royal jelly: Characterization, antioxidant, antibacterial activities and in vitro digestion

Unraveling the Chemistry of Curcumin for Colon Cancer Prevention and Treatment

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