68Ga-PSMA PET/CT imaging in primary hepatocellular carcinoma

68Ga-Labeled Prostate-Specific Membrane Antigen Is a Novel PET/CT Tracer for Imaging of Hepatocellular Carcinoma: A Prospective Pilot Study

“…The incidental uptake of 68 Ga-PSMA has been described in other solid tumors, including case reports of HCC (9)(10)(11). In the present prospective pilot study, we investigated the uptake of 68 Ga-PSMA and of the routinely used 18 F-FDG in patients with HCC and compared it to contrast enhancement on CT or MRI for a total of 41 liver lesions detected in 7 patients.…”

PSMA Ligands for PET Imaging of Prostate Cancer

“…Accordingly, there is increasing evidence that PSMA ligand uptake is not exclusively specific for PC. A large number of case series and reports describe increased PET signal in benign lesions (e.g., neurogenic tissue, Paget disease, thyroid adenoma, granulomatous disease, and adrenal adenoma) as well as in malignant diseases (e.g., renal cell carcinoma, lung cancer, glioblastoma, hepatocellular carcinoma, and thyroid cancer) (87)(88)(89)(90)(91)(92)(93)(94)(95). Supplemental Table 1 (supplemental materials are available at http://jnm.snmjournals.org) summarizes the current evidence in the literature.…”

PSMA Theranostics Using PET and Subsequent Radioguided Surgery in Recurrent Prostate Cancer

“…It has to be noted, however, that several reports have also described PSMA-avid lesions not related to PCa, and these differential diagnoses have to be considered when evaluating PSMA-based examinations. [12][13][14][15][16][17][18][19][20][21][22][23] However, current available clinical and preclinical studies show high image contrast and specificity, exemplarily demonstrated by this case, explaining the current fast distribution of PSMA-PET for the evaluation of PCa.…”