68Ga-PET Radiopharmacy: A Generator-Based Alternative to 18F-Radiopharmacy

68Ga-labeled DOTA-Peptides and 68Ga-labeled Radiopharmaceuticals for Positron Emission Tomography: Current Status of Research, Clinical Applications, and Future Perspectives

“…However, alternative chelators are still being developed, such as NOTAGA and acyclic chelates, all with their specific advantages and disadvantages. 3,7,18,19,[48][49][50] An additional beneficial effect of the presence of Ga 3ϩ in the DOTA cavity in DOTA-pharmaceuticals is the increased receptor affinity, as compared with other trivalent metals in the DOTA cavity such as In 3ϩ or Y 3ϩ , 8,35,45 probably because of differences in coordination chemistry. 3,9,51,52 …”

“…22,45,46 Somatostatin receptor-targeted imaging, initially with [ 123 ITyr 3 ]octreotide and later with [ 111 In-DTPA 0 ]octreotide (OctreoScan; Covedien, Hazelwood, MO), was important for imaging and diagnostics of neuroendocrine tumors in nuclear medicine. 3,7,19,47 Radiolabeled peptides targeting G protein-coupled receptors with DOTA as bifunctional chelator were developed and have shown in vivo stability, favorable pharmacokinetics (PK), and high and specific receptor-mediated tumor uptake. 11 Another boost for nuclear medicine came with the somatostatin receptor-targeting radiopeptide [ 68 Ga-DOTA 0 , Tyr 3 ]octreotide ( 68 Ga-DOTATOC; Fig.…”

“…Fifth, the availability of PET radiolabeled pharmaceuticals by the introduction of 68 Ga in radiopharmacy, independent of an on-site cyclotron, opened new applications and possibilities. Coupling of 68 Ga to small peptides and biomolecules was recently reviewed, 3,7,9,18,19 and 68 Ga is potentially an alternative to 18 F-and 11 C-based radiopharmacy. 19 Last but not least, equipment, including generators, purification and concentration of eluate, techniques of radiolabeling, robotics, and PET cameras, has improved during the last decade.…”

“…Coupling of 68 Ga to small peptides and biomolecules was recently reviewed, 3,7,9,18,19 and 68 Ga is potentially an alternative to 18 F-and 11 C-based radiopharmacy. 19 Last but not least, equipment, including generators, purification and concentration of eluate, techniques of radiolabeling, robotics, and PET cameras, has improved during the last decade. Preclinical application of many 68 Ga-labeled pharmaceuticals has been developed, and all of today's options with 99m Tc are potentially covered, for example, myocardial perfusion and function, blood flow, renal function, liver function, and clinical application (Mäcke and Andre, 19 Fani, et al, 7 Rösch and Riss, 3 Wadas, et al 9 ).…”

¹⁸F-ФДГ и другие меченые производные глюкозы для использования в радионуклидной диагностике онкологических заболеваний (обзор)

“…Àëüòåðíàòèâîé ÿâëÿåòñÿ èñïîëüçîâàíèå ãåíå-ðàòîðíûõ ðàäèîíóêëèäîâ äëÿ ïîëó÷åíèÿ ÐÔÏ, íàèáîëåå ïåðñïåêòèâíûì èç êîòîðûõ ÿâëÿåòñÿ ãàëëèé-68, ïî ñâîèì ÿäåðíî-ôèçè÷åñêèì ñâîéñòâàì óñòóïàþùèé ôòîðó-18, îäíàêî âîçìîaeíîñòü åãî ïîëó÷åíèÿ èç êîììåð÷åñêè äîñ-òóïíîãî ãåíåðàòîðà 68 Gå/ 68 Ga íåïîñðåäñòâåííî â ìåäè-öèíñêîì ó÷ðåaeäåíèè äàåò îãðîìíûå ïðåèìóùåñòâà [82,83]. Ïåðèîä ïîëóðàñïàäà ìàòåðèíñêîãî ðàäèîíóêëè-äà ãåðìàíèÿ-68 ñîñòàâëÿåò 288 ñóò, è ýòî îïðåäåëÿåò äîñ-òàòî÷íî áîëüøîé ñðîê ñëóaeáû ãåíåðàòîðà.…”