68Ga-FAPI-04 PET/CT, a new step in breast cancer imaging: a comparative pilot study with the 18F-FDG PET/CT

FAP and FAPI-PET/CT in Malignant and Non-Malignant Diseases: A Perfect Symbiosis?

“…In a prospective pilot study, Kömek et al analyzed 20 patients with primary or recurrent breast cancer and their metastases and subsequently compared the 68 Ga-FAPI-PET/CT sensitivity and specificity with those of 18 F-FDG. FAPI imaging had significantly higher SUV metrics and higher TBRs compared with FDG with the exception of liver lesions, which demonstrated no significant differences [117]. FAPI seems to be of a high interest in several gynecological malignancies as well.…”

Head-to-Head Comparison of Fibroblast Activation Protein Inhibitors (FAPI) Radiotracers versus [18F]F-FDG in Oncology: A Systematic Review

“…No additional studies were found screening the references of the selected articles. Finally, 26 articles (925 patients) including data on the comparison between radiolabeled FAPI and [ 18 F]F-FDG as PET radiotracers in oncology were included in the systematic review [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. The characteristics of the studies selected for the systematic review are presented in Table 1 , Table 2 , Table 3 .…”

“…Through the comprehensive computer literature search, 26 full-text articles including data on the head-to-head comparison of radiolabeled FAPI and [ 18 F]F-FDG in cancer patients were selected ( Table 1 ) [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. All the selected articles were published in the last two years.…”

“…Regarding the normal tissue biodistribution of radiolabeled FAPI in comparison to [ 18 F]F-FDG, all the included studies showed a lower radiolabeled FAPI uptake in the normal brain, liver, and oral mucosa, compared to [ 18 F]F-FDG [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ].…”

“…Overall, taking into account the radiotracer uptake and TBR values, compared to [ 18 F]F-FDG PET, an equal or higher detection of primary tumors and/or metastatic lesions was usually demonstrated by using radiolabeled FAPI PET [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. In particular, the cancer entities with better detection rate of tumor lesions by using radiolabeled FAPI PET compared to [ 18 F]F-FDG PET were gastrointestinal tumors, liver tumors, breast cancer and nasopharyngeal carcinoma.…”