68Ga-DOTATOC PET/CT and somatostatin receptor (sst1–sst5) expression in normal human tissue: correlation of sst2 mRNA and SUVmax

Boy, Christian; Heusner, Till A.; Poeppel, Thorsten D.; Redmann-Bischofs, Anja; Unger, Nicole; Jentzen, Walter; Brandau, Wolfgang; Mann, Klaus; Antoch, Gerald; Bockisch, Andreas; Petersenn, Stephan

doi:10.1007/s00259-011-1760-x

Cited by 110 publications

(78 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, intense 68 Ga-DOTANOC uptake is found in the pituitary, which is the only organ that shows consistently high sst 2 and sst 5 expression (25,33,34). Again, sst 5 -mediated accumulation of 68 Ga-DOTANOC might be the explanation for this finding.…”

Section: Discussionmentioning

confidence: 51%

See 1 more Smart Citation

Comparison of ⁶⁸Ga-DOTANOC and ⁶⁸Ga-DOTATATE PET/CT Within Patients with Gastroenteropancreatic Neuroendocrine Tumors

et al. 2013

View full text Add to dashboard Cite

Somatostatin receptor PET tracers such as [ 68 Ga-DOTA, 1-Nal 3 ]-octreotide ( 68 Ga-DOTANOC) and [ 68 Ga-DOTA,Tyr 3 ]-octreotate ( 68 Ga-DOTATATE) have shown promising results in patients with neuroendocrine tumors, with a higher lesion detection rate than is achieved with 18 F-fluorodihydroxyphenyl-Lalanine PET, somatostatin receptor SPECT, CT, or MR imaging. 68 Ga-DOTANOC has high affinity for somatostatin receptor subtypes 2, 3, and 5 (sst 2,3,5 ). It has a wider receptor binding profile than 68 Ga-DOTATATE, which is sst 2 -selective. The wider receptor binding profile might be advantageous for imaging because neuroendocrine tumors express different subtypes of somatostatin receptors. The goal of this study was to prospectively compare 68 Ga-DOTANOC and 68 Ga-DOTATATE PET/CT in the same patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and to evaluate the clinical impact of 68 Ga-DOTANOC PET/CT. Methods: Eighteen patients with biopsy-proven GEP-NETs were evaluated with 68 Ga-DOTANOC and 68 Ga-DOTATATE using a randomized crossover design. Labeling of DOTANOC and DOTATATE with 68 Ga was standardized using a fully automated synthesis device. PET/CT findings were compared with 3-phase CT scans and in some patients with MR imaging, 18 F-FDG PET/CT, and histology. Uptake in organs and tumor lesions was quantified and compared by calculation of maximum standardized uptake values (SUVmax) using volume computer-assisted reading. Results: Histology revealed low-grade GEP-NETs (G1) in 4 patients, intermediate grade (G2) in 7, and high grade (G3) in 7. 68 Ga-DOTANOC and 68 Ga-DOTATATE were false-negative in only 1 of 18 patients. In total, 248 lesions were confirmed by crosssectional and PET imaging. The lesion-based sensitivity of 68 Ga-DOTANOC PET was 93.5%, compared with 85.5% for 68 Ga-DOTATATE PET (P 5 0.005). The better performance of 68 Ga-DOTANOC PET is attributed mainly to the significantly higher detection rate of liver metastases rather than tumor differentiation grade. Multivariate analysis revealed significantly higher SUVmax in G1 tumors than in G3 tumors (P 5 0.009).This finding was less pronounced with 68 Ga-DOTANOC (P . 0.001). Altogether, 68 Ga-DOTANOC changed treatment in 3 of 18 patients (17%). Conclusion: The sst 2,3,5 -specific radiotracer 68 Ga-DOTANOC detected significantly more lesions than the sst 2 -specific radiotracer 68 Ga-DOTATATE in our patients with GEP-NETs. The clinical relevance of this finding has to be proven in larger studies.

show abstract

Section: Discussionmentioning

confidence: 51%

“…However, this is a difficult task because sst 1 -sst 5 in vitro detection has been studied with distinctly different methods (polymerase chain reaction [PCR], immunohistochemistry, autoradiography) with often contradictory results (25)(26)(27)(28)(29)(30)(31)(32)(33)(34).…”

Section: Discussionmentioning

confidence: 99%

Comparison of ⁶⁸Ga-DOTANOC and ⁶⁸Ga-DOTATATE PET/CT Within Patients with Gastroenteropancreatic Neuroendocrine Tumors

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Conversely, in a recently published study SSTR expression was highly expressed in normal thyroid tissue for SSTR1, SSTR3, SSTR4, and SSTR5, whilst SSTR 2a was not expressed at all [6]. Results depend on the investigation method used -expression of receptors at the level of mRNA SSTRs or IHC [1,6,[10][11][12].…”

Section: Ga-dotatate Pet/ct U Pacjenta Z Nen G1 żOłądka Z Widocznymmentioning

confidence: 81%

Jak często wykrywamy przypadkowe zmiany w tarczycy w badaniu PET/CT z 68Ga-DOTATATE u pacjentów diagnozowanych z powodu nowotworu neuroendokrynnego?

Kunikowska

Matyskiel

Zemczak

et al. 2015

Endokrynologia Polska

View full text Add to dashboard Cite

“…The most abundant SSTR subtype in the spleen was SSTR2 (79.7%) followed by SSTR1 (19.6%), SSTR4 (0.6%), SSTR3 (0.1%) and SSTR5 (0.0%) [11]. Significantly higher expression of SST2A mRNA in the spleen was demonstrated by quantitative reverse transcription polymerase chain reaction [12].…”

Section: Somatostatin and Somatostatin Receptorsmentioning

confidence: 90%

“…In various studies with Ga-68 DOTATOC, standardized uptake value (SUVmax) (mean ± standard deviation) in normal spleen was reported to be as 22.0 ± 10.0, 28.8 ± 12.5 and 31.1 ± 10.9 [11,31,44]. SSTR PET images provide higher resolution spleen images than SSTR SPECT does (Fig.…”

Section: Splenic Uptake On Sstr Imaging Studiesmentioning

confidence: 99%

Significance of splenic uptake on somatostatin receptor imaging studies

Sarıkaya¹,

Sarıkaya²,

Alnafisi³

et al. 2018

Nucl. Med. Rev.

View full text Add to dashboard Cite

Spleen shows a high physiological uptake on radionuclide somatostatin receptor (SSTR) imaging studies. Autoradiography and immunohistochemistry studies showed that SSTRs are mainly located in the red pulp of the spleen. In this review article we will summarize the significance of splenic uptake in SSTR imaging studies and will also present high resolution splenic images of Ga-68 DOTANOC PET in which splenic distribution of the radiotracer appears to be correlating with the distribution of red pulp.

show abstract

68Ga-DOTATOC PET/CT and somatostatin receptor (sst1–sst5) expression in normal human tissue: correlation of sst2 mRNA and SUVmax

Abstract: In normal human tissues (68)Ga-DOTATOC imaging has been related to the expression of sst2 at the level of mRNA. The novel normative database may improve diagnostics, monitoring and therapy of sst-expressing tumours or inflammation on a molecular basis.

Cited by 110 publications

References 36 publications

Comparison of ⁶⁸Ga-DOTANOC and ⁶⁸Ga-DOTATATE PET/CT Within Patients with Gastroenteropancreatic Neuroendocrine Tumors

Comparison of ⁶⁸Ga-DOTANOC and ⁶⁸Ga-DOTATATE PET/CT Within Patients with Gastroenteropancreatic Neuroendocrine Tumors

Jak często wykrywamy przypadkowe zmiany w tarczycy w badaniu PET/CT z 68Ga-DOTATATE u pacjentów diagnozowanych z powodu nowotworu neuroendokrynnego?

Significance of splenic uptake on somatostatin receptor imaging studies

Contact Info

Product

Resources

About

68Ga-DOTATOC PET/CT and somatostatin receptor (sst1–sst5) expression in normal human tissue: correlation of sst2 mRNA and SUVmax

Abstract: In normal human tissues (68)Ga-DOTATOC imaging has been related to the expression of sst2 at the level of mRNA. The novel normative database may improve diagnostics, monitoring and therapy of sst-expressing tumours or inflammation on a molecular basis.

Cited by 110 publications

References 36 publications

Comparison of 68Ga-DOTANOC and 68Ga-DOTATATE PET/CT Within Patients with Gastroenteropancreatic Neuroendocrine Tumors

Comparison of 68Ga-DOTANOC and 68Ga-DOTATATE PET/CT Within Patients with Gastroenteropancreatic Neuroendocrine Tumors

Jak często wykrywamy przypadkowe zmiany w tarczycy w badaniu PET/CT z 68Ga-DOTATATE u pacjentów diagnozowanych z powodu nowotworu neuroendokrynnego?

Significance of splenic uptake on somatostatin receptor imaging studies

Contact Info

Product

Resources

About

Comparison of ⁶⁸Ga-DOTANOC and ⁶⁸Ga-DOTATATE PET/CT Within Patients with Gastroenteropancreatic Neuroendocrine Tumors

Comparison of ⁶⁸Ga-DOTANOC and ⁶⁸Ga-DOTATATE PET/CT Within Patients with Gastroenteropancreatic Neuroendocrine Tumors