68Ga-Based Radiopharmaceuticals: Production and  Application Relationship

Velikyan, Irina

doi:10.3390/molecules200712913

Cited by 179 publications

(174 citation statements)

References 63 publications

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“…The results showed that the radiochemical purity of 68 Ga‐NOTA‐HL was not affected by addition of ascorbic acid. This may be due to the lack of radiolysis‐sensitive component (such as cysteine, methionine, and tryptophan amino acid residues) of NOTA‐HL . So stabilizer was not included in the kit formulation of NOTA‐HL.…”

Section: Discussionmentioning

confidence: 99%

Development of single vial kits for preparation of ⁶⁸Ga‐labelled hexavalent lactoside for PET imaging of asialoglycoprotein receptor

Chan

Chen

et al. 2018

Labelled Comp Radiopharmac

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The aim of this study was to formulate and evaluate the freeze-dried kit of NOTA-hexavalent lactoside (NOTA-HL) for the preparation of Ga-labeled glycoligand for PET imaging of the asialoglycoprotein receptor (ASGPR). GaCl was obtained from a commercial Ge/ Ga generator. Single-vial kits of HL were formulated. Optimization of radiolabeling with Ga, various evaluations of NOTA-HL kits, and in vitro stability study of Ga-HL were carried out. PET/CT imaging of normal mice injected with Ga-NOTA-HL was performed. NOTA-HL kit was successfully formulated. High radiochemical yields (>95%) were obtained by Ga radiolabeling. The NOTA-HL kits were stable for at least 12 months, and Ga-NOTA-HL exhibited good in vitro stability. PET studies in normal mice revealed high specific accumulation of activity in the liver. The NOTA-HL kit was developed for fast Ga labeling. Ga-NOTA-HL showed high specific uptake in liver. The availability of ready-to-use NOTA-HL kits combined with Ge/ Ga generators would provide an efficient approach for PET imaging of ASGPR.

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Section: Discussionmentioning

confidence: 99%

Development of single vial kits for preparation of ⁶⁸Ga‐labelled hexavalent lactoside for PET imaging of asialoglycoprotein receptor

Chan

Chen

et al. 2018

Labelled Comp Radiopharmac

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“…However, over time a small peak in the HPLC, corresponding to the retention time of the oxidized fluorophore, was evident. As this is likely due to the presence of radicals generated as a result of radioactive decay, the use of a radical scavenger was explored. Ascorbic acid, at concentrations suitable for preclinical and clinical studies (0.5 mg mL −1 ), was used as an antioxidant and proved to be highly effective as the probe showed no evidence of oxidation out to 150 min (Supporting Information, Figures S17 and S18).…”

Section: Methodsmentioning

confidence: 99%

Preparation of an ¹⁸F‐Labeled Hydrocyanine Dye as a Multimodal Probe for Reactive Oxygen Species

Al-Karmi

Albu

Vito

et al. 2016

Chemistry A European J

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Hydrocyanine dyes are sensitive "turn-on" type optical probes that can detect reactive oxygen species (ROS). We have developed a method to prepare an F-labeled hydrocyanine dye as a multi-modal PET and optical "turn-on" probe. A commercially available near infrared (NIR) dye was modified with a fluorinated prosthetic group that did not alter its ROS sensing properties in the presence of superoxide and hydroxyl radicals. The F-labeled analogue was produced using a single-step terminal fluorination procedure. Positron emission tomography (PET) imaging and quantitative in vivo biodistribution studies indicated this novel probe had remarkably different pharmacokinetics compared to the oxidized cyanine analogue. The chemistry reported enables the use of quantitative and dynamic PET imaging for the in vivo study of hydrocyanine dyes as ROS probes.

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“…The resulting specific activity, however, is often low. One such case is 153 Sm. It is extensively used in radiotherapy [218] but no suitable alternative to (n, ) reaction has been found (cf.…”

Section: Sementioning

confidence: 99%

“…[219]). In our laboratory the excitation function of the 140 Nd( ,n) 153 Sm reaction was investigated [220] and the result is promising. It could be used for production of no-carrier added ( ,p) 177m,g Lu, could also prove to be an interesting alternative production route, but so far it has not been investigated.…”

Section: Sementioning

confidence: 99%

Uses of alpha particles, especially in nuclear reaction studies and medical radionuclide production

et al. 2016

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Alpha particles exhibit three important characteristics: scattering, ionisation and activation. This article briefly discusses those properties and outlines their major applications. Among others, -particles are used in elemental analysis, investigation and improvement of materials properties, nuclear reaction studies and medical radionuclide production. The latter two topics, dealing with activation of target materials, are treated in some detail in this paper. Measurements of excitation functions of -particle induced reactions shed some light on their reaction mechanisms, and studies of isomeric cross sections reveal the probability of population of highspin nuclear levels. Regarding medical radionuclides, an overview is presented of the isotopes commonly produced using -particle beams. Consideration is also given to some routes which could be potentially useful for production of a few other radionuclides. The significance of -particle induced reactions to produce a few high-spin isomeric states, decaying by emission of low-energy conversion or Auger electrons, which are of interest in localised internal radiotherapy, is outlined. The -particle beam, thus broadens the scope of nuclear chemistry research related to development of non-standard positron emitters and therapeutic radionuclides.

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68Ga-Based Radiopharmaceuticals: Production and Application Relationship

Cited by 179 publications

References 63 publications

Development of single vial kits for preparation of ⁶⁸Ga‐labelled hexavalent lactoside for PET imaging of asialoglycoprotein receptor

Development of single vial kits for preparation of ⁶⁸Ga‐labelled hexavalent lactoside for PET imaging of asialoglycoprotein receptor

Preparation of an ¹⁸F‐Labeled Hydrocyanine Dye as a Multimodal Probe for Reactive Oxygen Species

Uses of alpha particles, especially in nuclear reaction studies and medical radionuclide production

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68Ga-Based Radiopharmaceuticals: Production and Application Relationship

Cited by 179 publications

References 63 publications

Development of single vial kits for preparation of 68Ga‐labelled hexavalent lactoside for PET imaging of asialoglycoprotein receptor

Development of single vial kits for preparation of 68Ga‐labelled hexavalent lactoside for PET imaging of asialoglycoprotein receptor

Preparation of an 18F‐Labeled Hydrocyanine Dye as a Multimodal Probe for Reactive Oxygen Species

Uses of alpha particles, especially in nuclear reaction studies and medical radionuclide production

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Development of single vial kits for preparation of ⁶⁸Ga‐labelled hexavalent lactoside for PET imaging of asialoglycoprotein receptor

Development of single vial kits for preparation of ⁶⁸Ga‐labelled hexavalent lactoside for PET imaging of asialoglycoprotein receptor

Preparation of an ¹⁸F‐Labeled Hydrocyanine Dye as a Multimodal Probe for Reactive Oxygen Species