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Abstract

Carbohydrate-based therapeutics are extremely potent, and many carbohydrate-based drugs are in the stage of preclinical or clinical trials. There is a growing interest in developing carbohydrate analogues for novel drug discovery as most of the recently used carbohydrate drugs display significant pharmacological activities and low toxicity. Also, the search for an antipyretic drug is a never-ending challenge. This research aimed at the development and synthesis of a series of amide-linked sugars (PV1-PV20) by coupling brominated sugars with varying amino acids coupled with nicotinic acid (GP1-GP10). Characterization of the derivatives synthesized was done by Infrared and Nuclear Magnetic Resonance Spectroscopy. These congeners were tested to analyze their antipyretic potential, and eight analogs out of twenty showed significant antipyretic activity. Thus, the carbohydratebased amide derivatives show important action in obstruction and therapy of fever. Further work on these lines may play an important role in maintaining good health at a low cost. INTRODUCTION:Oligosaccharides, carbohydrates and glycoconjugates are demanding ingredients for being alive. They intervene many crucial biological systems by cell-based complex operations which can trigger and assist life to percept developments required for disease related to autoimmune system, inflammation, and organ exclusion. The diversity of carbohydrate structures reflects that functional diversity. Natural and synthetic derivatives of carbohydrates have a good amount of therapeutic potential using them to treat various disorders 1 .