675 Left ventricular longitudinal function in hypertensive patients with left ventricular hypertrophy regression

Pavlyukova, E. N.; Bahmetiva, T.; Карпов, Р. С.

doi:10.1016/s1525-2167(06)60398-3

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2017

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“…Its development is influenced by interplay of genetic and non-genetic factors [2]. Poorly controlled hypertension has been implicated as the main reason for development of left ventricular hypertrophy (LVH) [3], however, the role of biochemical mediators such as angiotensin-II, endothelin-I, norepinephrine and urotensin-II cannot be overlooked [4]. Angiotensin-II plays a key role in homeostasis by regulating arterial tone and fluid balance [5], but becomes toxic to tissues in pathological states [6].…”

Section: Introductionmentioning

confidence: 99%

A Review on the Role of Chymase in Hypertensive Heart Disease

Boamah¹,

Armah²

2017

IJPHC

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Hypertensive heart disease is the commonest cardiac complication resulting from longstanding hypertension. Hypertensive patients inevitably develop hypertensive heart disease but the intensity and progression vary. Poor control is associated with a fast progression and worse outcome while the outcome of adequately controlled blood pressure is antithetical to the former. Various biochemical mediators have been implicated in hypertension and its related complications. Angiotensin-II is involved in both hypertension and remodeling of the cardiac and vascular architecture. The focus on Chymase and its inhibitors in modulating angiotensin-II levels have cast some doubts on the efficacy of solely using angiotensin converting enzyme inhibitors.

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