“…However, the incidence of contrast agent‐associated events varies depending on the clinical and hemostasiologic conditions (9, 10). For both complications, endothelial damage is at the forefront as the primary pathophysiologic mechanism (3, 14). To minimize these side effects in routine clinical application, the use of ionic contrast agents has been almost entirely abandoned in favor of non‐ionic contrast agents, which offer greater clinical safety owing to their lower allergic potential (4, 23).…”