661. Divergent Effects of Acute and Repeated Quetiapine Treatment on Dopamine System in Normal and Chronic Mild Stress Induced Hypodopaminergic States

Moreines, Jared; Owrutsky, Zoe; Gagnon, Kimberly G.; Grace, Anthony A.

doi:10.1016/j.biopsych.2017.02.1070

Cited by 1 publication

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“…One question would be how would a D2 antagonist improve DA system function in a depressed state? We have found recently that repeated treatment with the second-generation antipsychotic quetiapine to the CMS rat model of depression effectively reversed the decrease in DA neuron population activity ( Moreines et al, 2017 ). We believe this is due to the low-dose quetiapine activating the “silent” DA neurons to restore population activity, whereas the low level D2 blockade can be overcome via homeostatic compensation (e.g., increased D2 receptors, increased tyrosine hydroxylase activity, etc.).…”

Section: Antidepressants and The Reward-related Circuit In Mddmentioning

confidence: 99%

Dopamine System Dysregulation in Major Depressive Disorders

Belujon¹,

Grace²

2017

International Journal of Neuropsychopharmacology

522

328

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Anhedonia is considered a core feature of major depressive disorder, and the dopamine system plays a pivotal role in the hedonic deficits described in this disorder. Dopaminergic activity is complex and under the regulation of multiple brain structures, including the ventral subiculum of the hippocampus and the basolateral amygdala. Whereas basic and clinical studies demonstrate deficits of the dopaminergic system in depression, the origin of these deficits likely lies in dysregulation of its regulatory afferent circuits. This review explores the current information regarding the afferent modulation of the dopaminergic system and its relevance to major depressive disorder, as well as some of the system-level effects of novel antidepressants such as agomelatine and ketamine.

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Section: Antidepressants and The Reward-related Circuit In Mddmentioning

confidence: 99%