650 Expression of Cyclooxygenase- 2 in Patients With Hepatitis C Virus and the Effect of Interferon/Ribavirin Therapy

Assessment of Cox2 and CMV in patients with chronic HCV infection

“…over-expression of COX-2 in cirrhosis was apparent in a study that assess in patients with cirrhosis due to HBV and HCV infection while our series inclusive HCV infection patients Mohamed et al 28 Another study, we were able to express a significant relation found between overall COX-2 expression and viral load of the HCV-RNA. 29 while Waris and Siddiqui 30 was found the increase in Cox-2 mRNA expression in cells containing the HCV replicon, indicate that HCV gene expression control Cox-2 activity at the stage of transcription. Holt and Adams 31 who indicated that COX-2-derived mediators have special functions at various times in the pathogenesis of chronic hepatitis.…”

“…Holt and Adams 31 who indicated that COX-2-derived mediators have special functions at various times in the pathogenesis of chronic hepatitis. Yosry et al 29 suggest that COX-2 expression seems to be correlated between inflammatory activity of the liver of patients with chronic HCV infection and the response to antiviral treatment which was clear by the reduction of COX-2 expression. Also Manning et al 32 indicated that reduction of liver Cox-2 level after giving INF as treatment.…”