65 Intracerebroventricular Corticotropin-Releasing Factor (CRF) at Low Doses Induces a CRF1 Receptor-Mediated Visceral Analgesia in Male Rats Through Recruitment of Brain Oxytocin

Larauche, Muriel; Biraud, Mandy; Moussaoui, Nabila; Bae, Woo Kyung; Duboc, Henri; Million, Mulugeta; Liang, Honghui; Taché, Yvette

doi:10.1016/s0016-5085(16)30182-2

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“…Visceral hypersensitivity (VH) is the hallmark of IBS. 3,4 Therefore, further study of the pathogenesis of VH may reveal the mystery of IBS.…”

Section: Introductionmentioning

confidence: 99%

The Role of Intestinal Microbiota and Mast Cell in a Rat Model of Visceral Hypersensitivity

Dai

2020

J Neurogastroenterol Motil

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Background/Aims To explore the role of intestinal flora and mast cells in visceral hypersensitivity (VH). Methods The experimental animals were divided into 4 groups: control group, VH group, VH + VSL#3 group, and VH + ketotifen group. Stool samples were collected from each group (n = 3) for a further analysis using 16S ribosomal DNA gene sequence. Visceral sensitivity was evaluated by abdominal withdrawal reflex (AWR) score. Colon tissues of rats were obtained from each group. Mast cells were detected by toluidine blue staining. The degranulation of mast cells was assessed by transmission electron microscopy. Results VH rat model could successfully be induced by acetic acid enema combined with partial limb restraint method. Compared with rats in the control group, AWR score, number of mast cells, and degranulation of mast cells were increased in the VH rats, which could be reduced by administration of ketotifen or probiotic VSL#3. Clostridium sensu stricto 1 abundance was higher in the VH group compared to the control group, which could be restored by application of probiotic VSL#3. Conclusions Probiotic VSL#3 decreases visceral sensitivity in VH rats. The mechanism may be related to mast cell and intestinal flora. Change of Clostridium sensu stricto 1 abundance may be a basis for VH observed in irritable bowel syndrome and may be prevented by specific probiotic administration.

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“…Visceral hypersensitivity (VH) is the hallmark of IBS. 3,4 Therefore, further study of the pathogenesis of VH may reveal the mystery of IBS.…”

Section: Introductionmentioning

confidence: 99%

The Role of Intestinal Microbiota and Mast Cell in a Rat Model of Visceral Hypersensitivity

Dai

2020

J Neurogastroenterol Motil

View full text Add to dashboard Cite

show abstract

65 Intracerebroventricular Corticotropin-Releasing Factor (CRF) at Low Doses Induces a CRF1 Receptor-Mediated Visceral Analgesia in Male Rats Through Recruitment of Brain Oxytocin

Cited by 1 publication

References 0 publications

The Role of Intestinal Microbiota and Mast Cell in a Rat Model of Visceral Hypersensitivity

The Role of Intestinal Microbiota and Mast Cell in a Rat Model of Visceral Hypersensitivity

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