63Ni ECD-gas chromatographic determination of 2,4- and 2,6-diaminotoluene in polyurethane foam and their mutagenic in Salmonella typhimurium strains.

Development of an Ion-pair HPLC method for the determination of 2,4- and 2,6-toluendiamine in human plasma

“…Several hypotheses have been formulated and therefore the development of analytical methods for the determination of aromatic amines in human body fluids would be clinically significant for elucidating the degradation process and for monitoring exposure to TDAs during polyurethane synthesis. The literature contains reports of the analysis of 2,4-and 2,6-toluendiamines in body fluids [6][7][8] and other matrices including air [9,10], hair dyes [11], aqueous solutions from boilable cooking bags [12][13][14], and polyurethane foams [15]. Analysis is usually performed by gas chromatography [15][16][17][18][19], which necessitates cumbersome sample preparation.…”

“…The literature contains reports of the analysis of 2,4-and 2,6-toluendiamines in body fluids [6][7][8] and other matrices including air [9,10], hair dyes [11], aqueous solutions from boilable cooking bags [12][13][14], and polyurethane foams [15]. Analysis is usually performed by gas chromatography [15][16][17][18][19], which necessitates cumbersome sample preparation. HPLC methods with electrochemical [9,14] or UV detection [10,11,13,20] have also been described.…”